Synthesis of carbon‐14 labelled cis‐malonato [(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane] platinum(II) (ski 2053R)

Dae‐Kee ‐K Kim, Youngseok Kim, Jonggill Rim, Ganghyeok Kim, Jongsik Gam, Sungkun Song, Kwanghee Yoo, Key H. Kim

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The synthesis of 14C‐labelled cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II) from [1,4‐14C] D‐tartaric acid is described. The overall radiochemical yield of the product in a eight‐step sequence was 23.8% and radiochemical purity was 98.5%.

Original languageEnglish
Pages (from-to)157-164
Number of pages8
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Issue number2
StatePublished - Feb 1994


  • (amino[C]methyl)‐2‐isopropyl‐1,3‐dioxolane]platinum(II)
  • SKI 2053R[C]
  • anticancer agent
  • cis‐malonato[(4R,5R)‐4,5‐bis
  • radiosynthesis


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