Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir

Dae Kee Kim; Junwon Lee; Youngseok Kim; Namkyu Lee; Young Woo Kim; Kieyoung Chang; Jae Sun Kim; Kiseung Lee; Key H. Kim

doi:10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23

Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir

Dae Kee Kim, Junwon Lee, Youngseok Kim, Namkyu Lee, Young Woo Kim, Kieyoung Chang, Jae Sun Kim, Kiseung Lee, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The synthesis of ¹⁴C-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxy-but-1-yl)purine from [1-¹⁴C] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical purity was 98.5%.

Original language	English
Pages (from-to)	597-604
Number of pages	8
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	42
Issue number	6
DOIs	https://doi.org/10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23
State	Published - 1999

Keywords

2-Amino-9-(3-hydroxy[C]methyl-4-isopropoxycarbonyloxybut-1-yl)purine
Antiviral agent
Radiosynthesis
SK 1875 [C]

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Kim, D. K., Lee, J., Kim, Y., Lee, N., Kim, Y. W., Chang, K., Kim, J. S., Lee, K., & Kim, K. H. (1999). Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir. Journal of Labelled Compounds and Radiopharmaceuticals, 42(6), 597-604. https://doi.org/10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23

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title = "Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir",

abstract = "The synthesis of 14C-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxy-but-1-yl)purine from [1-14C] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical purity was 98.5%.",

keywords = "2-Amino-9-(3-hydroxy[C]methyl-4-isopropoxycarbonyloxybut-1-yl)purine, Antiviral agent, Radiosynthesis, SK 1875 [C]",

author = "Kim, {Dae Kee} and Junwon Lee and Youngseok Kim and Namkyu Lee and Kim, {Young Woo} and Kieyoung Chang and Kim, {Jae Sun} and Kiseung Lee and Kim, {Key H.}",

year = "1999",

doi = "10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23",

language = "English",

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Kim, DK, Lee, J, Kim, Y, Lee, N, Kim, YW, Chang, K, Kim, JS, Lee, K & Kim, KH 1999, 'Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, no. 6, pp. 597-604. https://doi.org/10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23

TY - JOUR

T1 - Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir

AU - Kim, Dae Kee

AU - Lee, Junwon

AU - Kim, Youngseok

AU - Lee, Namkyu

AU - Kim, Young Woo

AU - Chang, Kieyoung

AU - Kim, Jae Sun

AU - Lee, Kiseung

AU - Kim, Key H.

PY - 1999

Y1 - 1999

N2 - The synthesis of 14C-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxy-but-1-yl)purine from [1-14C] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical purity was 98.5%.

AB - The synthesis of 14C-2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxy-but-1-yl)purine from [1-14C] diethyl malonate is described. The overall radiochemical yield of the product in a nine-step sequence was 16.1%, and the compound's radiochemical purity was 98.5%.

KW - 2-Amino-9-(3-hydroxy[C]methyl-4-isopropoxycarbonyloxybut-1-yl)purine

KW - Antiviral agent

KW - Radiosynthesis

KW - SK 1875 [C]

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DO - 10.1002/(sici)1099-1344(199906)42:6<597::aid-jlcr220>3.0.co;2-%23

M3 - Article

AN - SCOPUS:0032994667

SN - 0362-4803

VL - 42

SP - 597

EP - 604

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 6

ER -

Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK 1875), a potential prodrug of penciclovir

Abstract

Keywords

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