Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity

Jin Kim Eun; Soo Y. Ko

doi:10.1016/j.bmc.2005.03.037

Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity

Jin Kim Eun, Soo Y. Ko

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A series of arylidene-substituted gelastatin analogues were synthesized in a divergent manner. Each analogue was obtained as a mixture of isomers. Calculation methods were devised to deduce the MMP-2 inhibitory activity of each isomer from the activity of an isomeric mixture and its composition. This protocol is suitable for rapidly generating a variety of arylidene-substituted gelastatin analogues and screening them for highly active inhibitors.

Original language	English
Pages (from-to)	4103-4112
Number of pages	10
Journal	Bioorganic and Medicinal Chemistry
Volume	13
Issue number	12
DOIs	https://doi.org/10.1016/j.bmc.2005.03.037
State	Published - 2 Jun 2005

Keywords

Gelastatin analogues
MMP-2 inhibitor
Screening

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10.1016/j.bmc.2005.03.037

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title = "Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity",

abstract = "A series of arylidene-substituted gelastatin analogues were synthesized in a divergent manner. Each analogue was obtained as a mixture of isomers. Calculation methods were devised to deduce the MMP-2 inhibitory activity of each isomer from the activity of an isomeric mixture and its composition. This protocol is suitable for rapidly generating a variety of arylidene-substituted gelastatin analogues and screening them for highly active inhibitors.",

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AU - Eun, Jin Kim

AU - Ko, Soo Y.

PY - 2005/6/2

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N2 - A series of arylidene-substituted gelastatin analogues were synthesized in a divergent manner. Each analogue was obtained as a mixture of isomers. Calculation methods were devised to deduce the MMP-2 inhibitory activity of each isomer from the activity of an isomeric mixture and its composition. This protocol is suitable for rapidly generating a variety of arylidene-substituted gelastatin analogues and screening them for highly active inhibitors.

AB - A series of arylidene-substituted gelastatin analogues were synthesized in a divergent manner. Each analogue was obtained as a mixture of isomers. Calculation methods were devised to deduce the MMP-2 inhibitory activity of each isomer from the activity of an isomeric mixture and its composition. This protocol is suitable for rapidly generating a variety of arylidene-substituted gelastatin analogues and screening them for highly active inhibitors.

KW - Gelastatin analogues

KW - MMP-2 inhibitor

KW - Screening

UR - https://www.scopus.com/pages/publications/19444386259

U2 - 10.1016/j.bmc.2005.03.037

DO - 10.1016/j.bmc.2005.03.037

M3 - Article

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AN - SCOPUS:19444386259

SN - 0968-0896

VL - 13

SP - 4103

EP - 4112

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 12

ER -

Synthesis of arylidene-substituted gelastatin analogues and their screening for MMP-2 inhibitory activity

Abstract

Keywords

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