Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Pramod K. Sahu; Gyudong Kim; Akshata Nayak; Ji Yoon Ahn; Min Woo Ha; Cheonhyoung Park; Jinha Yu; Hyeung geun Park; Lak Shin Jeong

doi:10.1002/ajoc.201500421

Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Pramod K. Sahu
, Gyudong Kim
, Akshata Nayak
, Ji Yoon Ahn
, Min Woo Ha
, Cheonhyoung Park
, Jinha Yu
, Hyeung geun Park
, Lak Shin Jeong

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Asian Journal of Organic Chemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/ajoc.201500421
State	Published - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Acyclic nucleoside phosphonates
Antivirals
Diselenides
Selenoadefovir
Selenotenofovir

Access to Document

10.1002/ajoc.201500421

Cite this

@article{2eeb6ac7134042c3b21409955859b21d,

title = "Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents",

abstract = "On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.",

keywords = "Acyclic nucleoside phosphonates, Antivirals, Diselenides, Selenoadefovir, Selenotenofovir",

author = "Sahu, \{Pramod K.\} and Gyudong Kim and Akshata Nayak and Ahn, \{Ji Yoon\} and Ha, \{Min Woo\} and Cheonhyoung Park and Jinha Yu and Park, \{Hyeung geun\} and Jeong, \{Lak Shin\}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH \& Co. KGaA, Weinheim.",

year = "2016",

month = feb,

day = "1",

doi = "10.1002/ajoc.201500421",

language = "English",

volume = "5",

pages = "183--186",

journal = "Asian Journal of Organic Chemistry",

issn = "2193-5807",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

AU - Sahu, Pramod K.

AU - Kim, Gyudong

AU - Nayak, Akshata

AU - Ahn, Ji Yoon

AU - Ha, Min Woo

AU - Park, Cheonhyoung

AU - Yu, Jinha

AU - Park, Hyeung geun

AU - Jeong, Lak Shin

PY - 2016/2/1

Y1 - 2016/2/1

N2 - On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

AB - On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

KW - Acyclic nucleoside phosphonates

KW - Antivirals

KW - Diselenides

KW - Selenoadefovir

KW - Selenotenofovir

UR - https://www.scopus.com/pages/publications/84959485099

U2 - 10.1002/ajoc.201500421

DO - 10.1002/ajoc.201500421

M3 - Article

AN - SCOPUS:84959485099

SN - 2193-5807

VL - 5

SP - 183

EP - 186

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

IS - 2

ER -

Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this