Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Pramod K. Sahu; Gyudong Kim; Akshata Nayak; Ji Yoon Ahn; Min Woo Ha; Cheonhyoung Park; Jinha Yu; Hyeung geun Park; Lak Shin Jeong

doi:10.1002/ajoc.201500421

Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Pramod K. Sahu, Gyudong Kim, Akshata Nayak, Ji Yoon Ahn, Min Woo Ha, Cheonhyoung Park, Jinha Yu, Hyeung geun Park, Lak Shin Jeong

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Asian Journal of Organic Chemistry
Volume	5
Issue number	2
DOIs	https://doi.org/10.1002/ajoc.201500421
State	Published - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

Acyclic nucleoside phosphonates
Antivirals
Diselenides
Selenoadefovir
Selenotenofovir

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10.1002/ajoc.201500421

Cite this

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abstract = "On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.",

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AU - Sahu, Pramod K.

AU - Kim, Gyudong

AU - Nayak, Akshata

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AU - Ha, Min Woo

AU - Park, Cheonhyoung

AU - Yu, Jinha

AU - Park, Hyeung geun

AU - Jeong, Lak Shin

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AB - On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

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KW - Selenotenofovir

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Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Abstract

Bibliographical note

Keywords

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