On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.
|Number of pages||4|
|Journal||Asian Journal of Organic Chemistry|
|State||Published - 1 Feb 2016|
- Acyclic nucleoside phosphonates