Synthesis of Acyclic Selenonucleoside Phosphonates as Potential Antiviral Agents

Pramod K. Sahu, Gyudong Kim, Akshata Nayak, Ji Yoon Ahn, Min Woo Ha, Cheonhyoung Park, Jinha Yu, Hyeung geun Park, Lak Shin Jeong

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

On the basis of potent antiviral activity of adefovir (1) and tenofovir (2), which are representative acyclic nucleoside phosphonates, bioisosteric acyclic selenonucleoside phosphonates seleno-adefovir (3) and seleno-tenofovir (4) were designed and synthesized from diethyl(iodomethyl)phosphonate (7) by using diselenide chemistry.

Original languageEnglish
Pages (from-to)183-186
Number of pages4
JournalAsian Journal of Organic Chemistry
Volume5
Issue number2
DOIs
StatePublished - 1 Feb 2016

Bibliographical note

Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

  • Acyclic nucleoside phosphonates
  • Antivirals
  • Diselenides
  • Selenoadefovir
  • Selenotenofovir

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