@article{765fb36068ab426483a3c2083818e4bf,
title = "Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase i and II inhibitory activity, cytotoxicity, and structure-activity relationship",
abstract = "Designed and synthesized were a series of 5H-chromeno[4,3-b]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Structure-activity relationship study showed that 2-furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity.",
keywords = "4-chromanone, Cytotoxicity, Terpyridine, Terthiophene, Topoisomerase I and II",
author = "Uttam Thapa and Pritam Thapa and Radha Karki and Minho Yun and Choi, {Jae Hun} and Yurngdong Jahng and Eunyoung Lee and Jeon, {Kyung Hwa} and Younghwa Na and Ha, {Eun Mi} and Cho, {Won Jea} and Youngjoo Kwon and Lee, {Eung Seok}",
note = "Funding Information: This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( 2010-0001661 , 2009-0066925 , 2010-0005506 and 2010-0002646 ).",
year = "2011",
month = aug,
doi = "10.1016/j.ejmech.2011.04.029",
language = "English",
volume = "46",
pages = "3201--3209",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier Masson s.r.l.",
number = "8",
}