Synthesis of 1,2,3-triazolium ionic liquid-supported chiral imidazolidinones and their application in asymmetric alkylation reaction

Yunkyung Jeong, Yunjeong Park, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

New 1,2,3-triazolium ionic liquid-supported chiral imidazolidinones were developed. The feasibility of the ionic liquid-supported imidazolidinones as chiral auxiliaries was demonstrated in sequential propionylation-alkylation-cleavage reactions, which provided the chiral product with good to excellent chemical yields (up to 90%) and high selectivities (up to 94% ee). The progress of the reactions could be monitored by TLC and NMR, and the ionic liquid-supported chiral auxiliaries could be recovered by simple extraction.

Original languageEnglish
Article number3349
JournalMolecules
Volume24
Issue number18
DOIs
StatePublished - 14 Sep 2019

Keywords

  • 2
  • 3-triazolium; chiral imidazolidinone; asymmetric alkylation; chiral auxiliaries
  • Ionic liquid; 1

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