Synthesis of 1 H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination

Areum Park; Kyu Sung Jeong; Hyuk Lee; Hyunwoo Kim

doi:10.1021/acsomega.1c00025

Synthesis of 1 H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination

Areum Park, Kyu Sung Jeong, Hyuk Lee, Hyunwoo Kim

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.

Original language	English
Pages (from-to)	6498-6508
Number of pages	11
Journal	ACS Omega
Volume	6
Issue number	9
DOIs	https://doi.org/10.1021/acsomega.1c00025
State	Published - 9 Mar 2021

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© 2021 The Authors. Published by American Chemical Society.

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abstract = "We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.",

author = "Areum Park and Jeong, {Kyu Sung} and Hyuk Lee and Hyunwoo Kim",

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AU - Lee, Hyuk

AU - Kim, Hyunwoo

PY - 2021/3/9

Y1 - 2021/3/9

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AB - We described a silver(I)-mediated intramolecular oxidative C-H amination that enables the construction of assorted 1H-indazoles that are widely applicable in medicinal chemistry. The developed amination was found to be efficient for the synthesis of a variety of 3-substituted indazoles that are otherwise difficult to be synthesized by other means of C-H aminations. Preliminary mechanistic studies suggested that the current amination proceeds via single electron transfer (SET) mediated by Ag(I) oxidant.

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Synthesis of 1 H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C-H Bond Amination

Abstract

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