Synthesis of α-methylene-δ-oxo-γ-amino esters: Via Rh(II)-catalyzed coupling of 1-sulfonyl-1,2,3-triazoles with Morita-Baylis-Hillman adducts

Hyun Ji Jeon, Mi Soo Kwak, Da Jung Jung, Jean Bouffard, Sang Gi Lee

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Abstract

A rhodium(ii)-catalyzed coupling of 1-sulfonyl-1,2,3-triazoles, prepared from 1-alkynes and sulfonyl azides, with Morita-Baylis-Hillman (MBH) adducts afforded highly functionalized α-methylene-δ-oxo-γ-amino esters in excellent yields with broad functional group tolerance. This transformation can also be successfully accomplished as a multicomponent all-in-one-pot reaction of 1-alkynes, sulfonyl azides and MBH adducts in the presence of Cu(i) and Rh(ii) catalysts.

Original languageEnglish
Pages (from-to)11238-11243
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number47
DOIs
StatePublished - 2016

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