Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Yeong Sang Kim, Kwan Mook Kim, Rita Song, Moo Jin Jun, Youn Soo Sohn

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalJournal of Inorganic Biochemistry
Issue number3
StatePublished - 2001

Bibliographical note

Funding Information:
This work was supported financially by the Ministry of Science and Technology and, in part, by the Basic Research Program of the Korea Science and Engineering Foundation.


  • Antitumor agents
  • Platinum
  • Quinolone


Dive into the research topics of 'Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates'. Together they form a unique fingerprint.

Cite this