Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Yeong Sang Kim, Kwan Mook Kim, Rita Song, Moo Jin Jun, Youn Soo Sohn

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.

Original languageEnglish
Pages (from-to)157-163
Number of pages7
JournalJournal of Inorganic Biochemistry
Volume87
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Antitumor agents
  • Platinum
  • Quinolone

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