Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Yeong Sang Kim; Kwan Mook Kim; Rita Song; Moo Jin Jun; Youn Soo Sohn

doi:10.1016/S0162-0134(01)00345-2

Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Yeong Sang Kim, Kwan Mook Kim, Rita Song, Moo Jin Jun, Youn Soo Sohn

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH₂)(dmso)X₂] and cis-[Pt(Q″-en)X₂], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X₂ is Cl₂ or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (¹H and ¹⁹⁵Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.

Original language	English
Pages (from-to)	157-163
Number of pages	7
Journal	Journal of Inorganic Biochemistry
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/S0162-0134(01)00345-2
State	Published - 2001

Bibliographical note

Funding Information:
This work was supported financially by the Ministry of Science and Technology and, in part, by the Basic Research Program of the Korea Science and Engineering Foundation.

Keywords

Antitumor agents
Platinum
Quinolone

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10.1016/S0162-0134(01)00345-2

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title = "Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates",

abstract = "A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.",

keywords = "Antitumor agents, Platinum, Quinolone",

author = "Kim, {Yeong Sang} and Kim, {Kwan Mook} and Rita Song and Jun, {Moo Jin} and Sohn, {Youn Soo}",

note = "Funding Information: This work was supported financially by the Ministry of Science and Technology and, in part, by the Basic Research Program of the Korea Science and Engineering Foundation.",

year = "2001",

doi = "10.1016/S0162-0134(01)00345-2",

language = "English",

volume = "87",

pages = "157--163",

journal = "Journal of Inorganic Biochemistry",

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T1 - Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

AU - Kim, Yeong Sang

AU - Kim, Kwan Mook

AU - Song, Rita

AU - Jun, Moo Jin

AU - Sohn, Youn Soo

N1 - Funding Information: This work was supported financially by the Ministry of Science and Technology and, in part, by the Basic Research Program of the Korea Science and Engineering Foundation.

PY - 2001

Y1 - 2001

N2 - A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.

AB - A new series of quinolone-platinum(II) conjugates, [Pt(Q′-NH2)(dmso)X2] and cis-[Pt(Q″-en)X2], where Q′ and Q″ are quinolones (flumequine, nalidixic acid or oxolinic acid) linked to monodentate and bidentate amine ligands, respectively, and X2 is Cl2 or 1,1-cyclobutanedicarboxylate, have been synthesized with the aim of examining the synergetic antitumor activity of quinolone intercalation and platinum(II) chelation. The complexes were characterized by elemental analyses and IR and multinuclear (1H and 195Pt) NMR spectroscopies, and then subjected to in vitro and in vivo bioassays using the leukemia L1210 cell line.

KW - Antitumor agents

KW - Platinum

KW - Quinolone

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U2 - 10.1016/S0162-0134(01)00345-2

DO - 10.1016/S0162-0134(01)00345-2

M3 - Article

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AN - SCOPUS:0035197497

SN - 0162-0134

VL - 87

SP - 157

EP - 163

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 3

ER -

Synthesis, characterization and antitumor activity of quinolone-platinum(II) conjugates

Abstract

Bibliographical note

Keywords

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