Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand

Hae Jin Kim; Kwan Mook Kim; Rita Song; Youn Soo Sohn

doi:10.1016/j.ica.2004.07.037

Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand

Hae Jin Kim, Kwan Mook Kim, Rita Song, Youn Soo Sohn

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mono(trifluoroacetato)platinum(IV) complexes of the formula [Pt ^IV(dach)L₃(TFAc)] (dach = trans-(±)-1,2- diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt^IV(dach)L₃(OH)] with trifluoroacetic anhydride in the presence of a base. Mono(trifluoroacetato) platinum(IV) complexes of the formula [Pt^IV(dach)L₃(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt ^IV(dach)L₃(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED₅₀ = 3.1 μM) was found to be much higher than carboplatin (ED₅₀ = 10.2 μM).

Original language	English
Pages (from-to)	415-418
Number of pages	4
Journal	Inorganica Chimica Acta
Volume	358
Issue number	2
DOIs	https://doi.org/10.1016/j.ica.2004.07.037
State	Published - 25 Jan 2005

Bibliographical note

Funding Information:
This research was supported by Korea Research Foundation Grant (KRF-2001-042-D0054).

Keywords

Antitumor drug
Electrophilic substitution
Platinum(IV)

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title = "Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand",

abstract = "Mono(trifluoroacetato)platinum(IV) complexes of the formula [Pt IV(dach)L3(TFAc)] (dach = trans-(±)-1,2- diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [PtIV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base. Mono(trifluoroacetato) platinum(IV) complexes of the formula [PtIV(dach)L3(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt IV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED50 = 3.1 μM) was found to be much higher than carboplatin (ED50 = 10.2 μM).",

keywords = "Antitumor drug, Electrophilic substitution, Platinum(IV)",

author = "Kim, {Hae Jin} and Kim, {Kwan Mook} and Rita Song and Sohn, {Youn Soo}",

note = "Funding Information: This research was supported by Korea Research Foundation Grant (KRF-2001-042-D0054). ",

year = "2005",

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AU - Kim, Hae Jin

AU - Kim, Kwan Mook

AU - Song, Rita

AU - Sohn, Youn Soo

N1 - Funding Information: This research was supported by Korea Research Foundation Grant (KRF-2001-042-D0054).

PY - 2005/1/25

Y1 - 2005/1/25

N2 - Mono(trifluoroacetato)platinum(IV) complexes of the formula [Pt IV(dach)L3(TFAc)] (dach = trans-(±)-1,2- diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [PtIV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base. Mono(trifluoroacetato) platinum(IV) complexes of the formula [PtIV(dach)L3(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt IV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED50 = 3.1 μM) was found to be much higher than carboplatin (ED50 = 10.2 μM).

AB - Mono(trifluoroacetato)platinum(IV) complexes of the formula [Pt IV(dach)L3(TFAc)] (dach = trans-(±)-1,2- diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [PtIV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base. Mono(trifluoroacetato) platinum(IV) complexes of the formula [PtIV(dach)L3(TFAc)] (dach = trans-(±)-1,2-diaminocyclohexane, TFAc = trifluoroacetate, L = acetate or propionate) could be prepared from the reaction of [Pt IV(dach)L3(OH)] with trifluoroacetic anhydride in the presence of a base and the crystal structure of compound 4 was determined by X-ray crystallography. In vitro antitumor activity of complex 4 (ED50 = 3.1 μM) was found to be much higher than carboplatin (ED50 = 10.2 μM).

KW - Antitumor drug

KW - Electrophilic substitution

KW - Platinum(IV)

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DO - 10.1016/j.ica.2004.07.037

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JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

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ER -

Synthesis and the structure of mixed carboxylatoplatinum(IV) complexes involving one trifluoroacetate ligand

Abstract

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Keywords

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