Abstract
Novel (diamine)platinum(II) complexes of the isomeric pyridine carboxylate ligands [A2Pt(PyCA)x](PyCA)2-x (A2=2,2′-dimethyl-1,3-propanediamine (dmpda), trans-(±)-1,2-diaminocyclohexane (dach), ethylenediamine (en), PyCA=picolinate (pic), nicotinate (nic), and isonicotinate (isonic), x=1 or 2) have been prepared from the reaction of (diamine)Pt(SO4) and Ba[PyCA]2 in aqueous solution. All products were obtained as crystals. Different coordination modes were observed depending on the position of the carboxylate group on the pyridine ring. Picolinate with the carboxylate group in the ortho-position chelated the platinum(II) atom by a (N,O) chelation mode resulting in the formation of a cationic complex. However, nicotinate and isonicotinate with the carboxylate group in meta- and para-positions, respectively, did not chelate but coordinated to the platinum(II) atom through their nitrogen atoms resulting in the formation of zwitterionic complexes. [(dmpda)Pt(pic)]+(pic)- crystallizes in the monoclinic system, space group P21/c (No. 14) with a=9.586(4), b=10.797(2), c=18.460(4) Å; β=100.267(2)°, V=1880.1(9) Å3 and Z=4, and (dmpda)Pt(isonic)2 crystallizes in the triclinic system, space group P1̄ (No. 2) with a=8.721(14), b=10.981(3), c=15.093(3) Å; α=80.10(2), β=74.48(14), γ=70.2(18)°; V=1305.9(5) Å3 and Z=2. Some of these compounds exhibit a significant antitumor activity in vitro against mouse leukemia cell line, which is comparable to that of carboplatin.
Original language | English |
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Pages (from-to) | 238-243 |
Number of pages | 6 |
Journal | Inorganica Chimica Acta |
Volume | 292 |
Issue number | 2 |
DOIs | |
State | Published - 15 Sep 1999 |
Bibliographical note
Funding Information:This research was financially supported by KOSEF and the Ministry of Science and Technology, South Korea.
Keywords
- Antitumor activity
- Crystal structures
- Diamine complexes
- Platinum complexes