Synthesis and oral antitumor activity of tetrakis(carboxylato)platinum(IV) complexes

Young A. Lee, Sung Sil Lee, Kwan Mook Kim, Chong Ock Lee, Youn Soo Sohn

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A novel class of tetrakis(carboxylato)platinum(IV) complexes, [Pt(O2CR)4(dach)] (dach = trans(±)-1,2-diaminocyclohexane; R = C(n)H(2n+1), n = 1 ~ 5), was synthesized and studied for physicochemical properties and oral antitumor activity. Lipophilicity and aqueous solubility of the title complexes were greatly dependent on the alkyl chain length of the carboxylate ligand, and their partition coefficient and solubility changed by 4 or 5 orders of magnitude from acetate to hexanoate complexes. On the other hand, the range of their cathodic reduction potential (-546 ~ -403 mV) depending on the chain length of the carboxylate ligand was relatively small. Among the title complexes, the tetrakis(propionato)platinum(IV) complex, [Pt(O2CC2H5)4(dach)], with appropriate lipophilicity (log P = 0.18) and aqueous solubility (14.6 mg/mL) was found to exhibit better oral antitumor activity than JM216 against the human ovarian tumor xenograft SKOV3 in nude mice.

Original languageEnglish
Pages (from-to)1409-1412
Number of pages4
JournalJournal of Medicinal Chemistry
Volume43
Issue number7
DOIs
StatePublished - 6 Apr 2000

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