TY - JOUR
T1 - Synthesis and in vitro cytotoxicity of cis-(glycolato-O,O')-[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II)
AU - Kim, Dae Kee
AU - Gam, Jongsik
AU - Kim, Hun Taek
AU - Kim, Key H.
PY - 1996/4/9
Y1 - 1996/4/9
N2 - The synthesis and in vitro cytotoxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) are described. Among them, cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2,2-diethyl-1,3-dioxolane] platinum(II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III.
AB - The synthesis and in vitro cytotoxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) are described. Among them, cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2,2-diethyl-1,3-dioxolane] platinum(II) (26) was found to be almost equally cytotoxic to cisplatin against two human non-small cell lung cancer cell lines, PC-9 and PC-14, and two human stomach cancer cell lines, MKN-45 and KATO III.
UR - http://www.scopus.com/inward/record.url?scp=0029876141&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(96)00126-6
DO - 10.1016/0960-894X(96)00126-6
M3 - Article
AN - SCOPUS:0029876141
SN - 0960-894X
VL - 6
SP - 771
EP - 774
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -
