TY - JOUR
T1 - Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)
AU - Kim, Dae Kee
AU - Kim, Young Woo
AU - Kim, Hun Taek
AU - Kim, Key H.
PY - 1996/3/19
Y1 - 1996/3/19
N2 - cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.
AB - cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxyp yrrolidine]-platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinu m(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.
UR - http://www.scopus.com/inward/record.url?scp=0029932154&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(96)00088-1
DO - 10.1016/0960-894X(96)00088-1
M3 - Article
AN - SCOPUS:0029932154
SN - 0960-894X
VL - 6
SP - 643
EP - 646
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 6
ER -
