Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes

Dae Kee Kim; Jongsik Gam; Key H. Kim

doi:10.1016/S0960-894X(01)80262-6

Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes

Dae Kee Kim
, Jongsik Gam
, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.

Original language	English
Pages (from-to)	911-916
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/S0960-894X(01)80262-6
State	Published - 1994

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10.1016/S0960-894X(01)80262-6

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title = "Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes",

abstract = "The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.",

author = "Kim, \{Dae Kee\} and Jongsik Gam and Kim, \{Key H.\}",

year = "1994",

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T1 - Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes

AU - Kim, Dae Kee

AU - Gam, Jongsik

AU - Kim, Key H.

PY - 1994

Y1 - 1994

N2 - The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.

AB - The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.

UR - https://www.scopus.com/pages/publications/0028213766

U2 - 10.1016/S0960-894X(01)80262-6

DO - 10.1016/S0960-894X(01)80262-6

M3 - Article

AN - SCOPUS:0028213766

SN - 0960-894X

VL - 4

SP - 911

EP - 916

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 7

ER -

Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes

Abstract

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