TY - JOUR
T1 - Synthesis and in vitro cytotoxicity of 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes
AU - Kim, Dae Kee
AU - Gam, Jongsik
AU - Kim, Key H.
PY - 1994
Y1 - 1994
N2 - The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.
AB - The synthesis and in vitro cytotoxicity of novel 1,3-dioxolane-2-(2-ethanamine)-2-methanamine platinum(II) complexes having a seven-membered ring structure are described. It has been demonstrated that cisplatin-resistant murine L1210 leukemia cells have lower cross-resistance to this class of compounds than to cisplatin and carboplatin, and the human stomach cancer cell lines, SNU-1, SNU-5, and SNU-16, are highly sensitive to the members of this class.
UR - http://www.scopus.com/inward/record.url?scp=0028213766&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(01)80262-6
DO - 10.1016/S0960-894X(01)80262-6
M3 - Article
AN - SCOPUS:0028213766
SN - 0960-894X
VL - 4
SP - 911
EP - 916
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 7
ER -
