Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

Seikwan Oh, Soyong Jang, Donghyun Kim, Inn Oc Han, Jae Chul Jung

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

Original languageEnglish
Pages (from-to)469-475
Number of pages7
JournalArchives of Pharmacal Research
Volume29
Issue number6
DOIs
StatePublished - 30 Jun 2006

Keywords

  • Anti-excitotoxicity
  • Benzylideneacetophenones
  • Cytotoxicity
  • Free-radical scavenging
  • Grignard reaction
  • NO generation
  • Synthesis

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