Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

Seikwan Oh; Soyong Jang; Donghyun Kim; Inn Oc Han; Jae Chul Jung

doi:10.1007/BF02969418

Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

Seikwan Oh, Soyong Jang, Donghyun Kim, Inn Oc Han, Jae Chul Jung

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

Original language	English
Pages (from-to)	469-475
Number of pages	7
Journal	Archives of Pharmacal Research
Volume	29
Issue number	6
DOIs	https://doi.org/10.1007/BF02969418
State	Published - 30 Jun 2006

Bibliographical note

Funding Information:
This work has been supported by a KOSEF Brain Neurobiology Grant (2005).

Keywords

Anti-excitotoxicity
Benzylideneacetophenones
Cytotoxicity
Free-radical scavenging
Grignard reaction
NO generation
Synthesis

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10.1007/BF02969418

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@article{b422d91949fd43e2beea6870c07a32ae,

title = "Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives",

abstract = "A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.",

keywords = "Anti-excitotoxicity, Benzylideneacetophenones, Cytotoxicity, Free-radical scavenging, Grignard reaction, NO generation, Synthesis",

author = "Seikwan Oh and Soyong Jang and Donghyun Kim and Han, {Inn Oc} and Jung, {Jae Chul}",

note = "Funding Information: This work has been supported by a KOSEF Brain Neurobiology Grant (2005).",

year = "2006",

month = jun,

day = "30",

doi = "10.1007/BF02969418",

language = "English",

volume = "29",

pages = "469--475",

journal = "Archives of Pharmacal Research",

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TY - JOUR

T1 - Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

AU - Oh, Seikwan

AU - Jang, Soyong

AU - Kim, Donghyun

AU - Han, Inn Oc

AU - Jung, Jae Chul

N1 - Funding Information: This work has been supported by a KOSEF Brain Neurobiology Grant (2005).

PY - 2006/6/30

Y1 - 2006/6/30

N2 - A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

AB - A series of yakuchinone B 1f and its analogs 1a-e was synthesized and evaluated for free radical scavenging, suppression of LPS-induced NO generation, cytotoxicity and anti-excitotoxicity in vitro. Compound 1c exhibited potent anti-excitotoxicity, while all compounds 1a-f showed considerable effects of free radical scavenging, suppression of LPS-induced NO generation, and cytotoxicity in microglia.

KW - Anti-excitotoxicity

KW - Benzylideneacetophenones

KW - Cytotoxicity

KW - Free-radical scavenging

KW - Grignard reaction

KW - NO generation

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=33746117600&partnerID=8YFLogxK

U2 - 10.1007/BF02969418

DO - 10.1007/BF02969418

M3 - Article

C2 - 16833013

AN - SCOPUS:33746117600

SN - 0253-6269

VL - 29

SP - 469

EP - 475

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 6

ER -

Synthesis and evaluation of biological properties of benzylideneacetophenone derivatives

Abstract

Bibliographical note

Keywords

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