Abstract
A series of benzo-annulated rutaecarpines were prepared from anthranilic acid and 3-aminonaphthalene-2- carboxylic acid by Fischer indole synthesis as key reaction. Cytotoxicity was somewhat increased by the introduction of benzo-annulation, which was not directly related to the inhibitory activity against topoisomerases (topo) I and II. Benzo-annulation on ring A led to significant increase of inhibitory activity against topo II while annulations on ring E increased inhibitory activity against topo I.
| Original language | English |
|---|---|
| Pages (from-to) | 1704-1709 |
| Number of pages | 6 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 33 |
| Issue number | 10 |
| DOIs | |
| State | Published - 2010 |
Keywords
- Benzorutaecarpine
- Cytotoxicity
- Fischer indole synthesis
- Rutaecarpine
- Topoisomerase