Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Dae Kee Kim; Jin Hwi Lim; Jung A. Lee; Purushottam M. Dewang

doi:10.1016/j.bmcl.2008.06.007

Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Dae Kee Kim
, Jin Hwi Lim
, Jung A. Lee
, Purushottam M. Dewang

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH₂-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC₅₀ values 27.6, 28, and 31 nM, respectively.

Original language	English
Pages (from-to)	4006-4010
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2008.06.007
State	Published - 15 Jul 2008

Keywords

Antiinflammatory
Trisubstituted imidazole
p38α MAP kinase inhibitors

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10.1016/j.bmcl.2008.06.007

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abstract = "A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.",

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author = "Kim, \{Dae Kee\} and Lim, \{Jin Hwi\} and Lee, \{Jung A.\} and Dewang, \{Purushottam M.\}",

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AU - Kim, Dae Kee

AU - Lim, Jin Hwi

AU - Lee, Jung A.

AU - Dewang, Purushottam M.

PY - 2008/7/15

Y1 - 2008/7/15

N2 - A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.

AB - A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.

KW - Antiinflammatory

KW - Trisubstituted imidazole

KW - p38α MAP kinase inhibitors

UR - https://www.scopus.com/pages/publications/47149103821

U2 - 10.1016/j.bmcl.2008.06.007

DO - 10.1016/j.bmcl.2008.06.007

M3 - Article

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AN - SCOPUS:47149103821

SN - 0960-894X

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 14

ER -

Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Abstract

Keywords

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