TY - JOUR
T1 - Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase
AU - Kim, Dae Kee
AU - Lim, Jin Hwi
AU - Lee, Jung A.
AU - Dewang, Purushottam M.
PY - 2008/7/15
Y1 - 2008/7/15
N2 - A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.
AB - A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.
KW - Antiinflammatory
KW - Trisubstituted imidazole
KW - p38α MAP kinase inhibitors
UR - http://www.scopus.com/inward/record.url?scp=47149103821&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.06.007
DO - 10.1016/j.bmcl.2008.06.007
M3 - Article
C2 - 18571921
AN - SCOPUS:47149103821
SN - 0960-894X
VL - 18
SP - 4006
EP - 4010
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 14
ER -