Synthesis and biological evaluation of trisubstituted imidazole derivatives as inhibitors of p38α mitogen-activated protein kinase

Dae Kee Kim, Jin Hwi Lim, Jung A. Lee, Purushottam M. Dewang

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

A series of trisubstituted imidazole derivatives containing a 4-fluorophenyl group, a pyrimidine ring, and a CN- or CONH2-substituted benzyl moiety have been synthesized and evaluated for p38α MAP kinase inhibitory activity. Among them, compounds 22c, 27b, and 28b inhibited p38α MAP kinase with IC50 values 27.6, 28, and 31 nM, respectively.

Original languageEnglish
Pages (from-to)4006-4010
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number14
DOIs
StatePublished - 15 Jul 2008

Keywords

  • Antiinflammatory
  • p38α MAP kinase inhibitors
  • Trisubstituted imidazole

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