Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison

Radha Karki, Chanmi Park, Kyu Yeon Jun, Tara Man Kadayat, Eung Seok Lee, Youngjoo Kwon

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Dihydroxylated 2,4-diphenyl-6-aryl pyridine derivatives were simply achieved using Claisen-Schmidt condensation reaction and modified Kröhnke pyridine synthetic method. Total forty-five compounds were designed and synthesized which contain hydroxyl groups at ortho, meta or para position of 2-and 4-phenyl rings attached to the central pyridine. They were evaluated for topoisomerase I and II inhibitory activity, and cytotoxicity against several human cancer cell lines for the development of novel antitumor agents. Most of the prepared compounds exhibited significant antiproliferative activity on human cancer cell lines, HCT15 and K562, as well as potent topo II inhibitory activity comparable to or stronger than etoposide. The structure-activity relationship demonstrated that compounds with hydroxyl group at meta or para position of 2-phenyl ring in combination with hydroxyl at ortho, meta or para position of 4-phenyl ring displayed the most potent topoisomerase II inhibitory activity and cytotoxicity. Positive correlation between topoisomerase II inhibition and cytotoxicity was obtained for several compounds (30, 35, 36, 40-45, 49, 54, 56). Compound 56 showed the most potent topoisomerase II inhibitory activity at low concentration and functioned as a topoisomerase poison like the mode of action of etoposide.

Original languageEnglish
Pages (from-to)360-378
Number of pages19
JournalEuropean Journal of Medicinal Chemistry
Volume90
DOIs
StatePublished - 27 Jan 2015

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Masson SAS.

Keywords

  • Antitumor agents
  • Cytotoxicity
  • Dihydroxylated 2 4-diphenyl-6-aryl
  • Terpyridine bioisosteres
  • Topoisomerase poison
  • pyridine

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