Synthesis and antitumor activity of 4-hydroxycoumarin derivatives

Jae Chul Jung, Ji Ho Lee, Seikwan Oh, Jae Gon Lee, Oee Sook Park

Research output: Contribution to journalArticlepeer-review

85 Scopus citations

Abstract

A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity against five human tumor cell lines. A series of 4-hydroxycoumarin derivatives was prepared and evaluated for antitumor activity. The key fragments were 2a-c, 5c, 12b, 13b, 17, and 18 which were prepared via dianion ring cyclization, Friedel-Crafts acylation, and Reformatsky reaction. Compound 20b showed the most potent antitumor activity among the total 12 derivatives and compounds 19a and 19b exhibited efficacy comparable to etoposide in vitro antitumor activity.

Original languageEnglish
Pages (from-to)5527-5531
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number22
DOIs
StatePublished - 15 Nov 2004

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