Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes

Dae Kee Kim; Jongsik Gam; Yong Baik Cho; Hun Taek Kim; Key H. Kim

doi:10.1016/0960-894X(96)00089-3

Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes

Dae Kee Kim
, Jongsik Gam
, Yong Baik Cho
, Hun Taek Kim
, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.

Original language	English
Pages (from-to)	647-652
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	6
Issue number	6
DOIs	https://doi.org/10.1016/0960-894X(96)00089-3
State	Published - 19 Mar 1996

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title = "Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes",

abstract = "The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with \% T/C values of around 200.",

author = "Kim, \{Dae Kee\} and Jongsik Gam and Cho, \{Yong Baik\} and Kim, \{Hun Taek\} and Kim, \{Key H.\}",

year = "1996",

month = mar,

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doi = "10.1016/0960-894X(96)00089-3",

language = "English",

volume = "6",

pages = "647--652",

journal = "Bioorganic and Medicinal Chemistry Letters",

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TY - JOUR

T1 - Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes

AU - Kim, Dae Kee

AU - Gam, Jongsik

AU - Cho, Yong Baik

AU - Kim, Hun Taek

AU - Kim, Key H.

PY - 1996/3/19

Y1 - 1996/3/19

N2 - The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.

AB - The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.

UR - https://www.scopus.com/pages/publications/0029964025

U2 - 10.1016/0960-894X(96)00089-3

DO - 10.1016/0960-894X(96)00089-3

M3 - Article

AN - SCOPUS:0029964025

SN - 0960-894X

VL - 6

SP - 647

EP - 652

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes

Abstract

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