TY - JOUR
T1 - Synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes
AU - Kim, Dae Kee
AU - Gam, Jongsik
AU - Cho, Yong Baik
AU - Kim, Hun Taek
AU - Kim, Key H.
PY - 1996/3/19
Y1 - 1996/3/19
N2 - The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.
AB - The synthesis and antitumor activity of (2R,3R)-2,3-dihydroxy- and -2,3-dialkoxy-1,4-diaminobutane platinum(II) complexes 10-15 are described. cis-Dichloro[(2R,3R)-2,3-dimethoxy-1,4-diaminobutane]platinum(II) (11) and cis-(cyclobutane-1,1-dicarboxylato)[(2R,3R)-2,3-dihydroxy-1,4-diaminob utane]platinum(II) (13) showed the potent antitumor activity against L1210 leukemia in mice with % T/C values of around 200.
UR - http://www.scopus.com/inward/record.url?scp=0029964025&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(96)00089-3
DO - 10.1016/0960-894X(96)00089-3
M3 - Article
AN - SCOPUS:0029964025
SN - 0960-894X
VL - 6
SP - 647
EP - 652
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 6
ER -