Abstract
Based on the potent anti-HIV activity of l-2′,3′-dideoxycytidine (l-ddC), l-2′,3′-dideoxy-4′-selenonucleosides (l-4′-Se-ddNs) have been synthesized from natural chiral template, l-glutamic acid, using Pummerer-type condensation as a key step. All synthesized compounds were assayed for anti-HIV-1 activity, but none of them did show any significant antiviral activity up to 100 μM, probably due to conformational differences between l-ddC and l-4′-Se-ddC, induced by the bulky selenium atom, which might play an important role in phosphorylation by cellular kinase.
| Original language | English |
|---|---|
| Pages (from-to) | 780-789 |
| Number of pages | 10 |
| Journal | Archives of Pharmacal Research |
| Volume | 42 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1 Sep 2019 |
Bibliographical note
Publisher Copyright:© 2019, The Pharmaceutical Society of Korea.
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This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Antiviral
- Pummerer-type condensation
- l-2′,3′-Dideoxy-4′-selenonucleosides
- l-4′-Se-ddC
- l-Nucleoside
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