Synthesis and anti-HCMV activity of 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine, an isostere of PMEG monoethyl ester

Dae Kee Kim; Young Woo Kim; Key H. Kim

doi:10.1016/S0960-894X(00)80078-5

Synthesis and anti-HCMV activity of 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine, an isostere of PMEG monoethyl ester

Dae Kee Kim, Young Woo Kim, Key H. Kim

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

The synthesis and anti-HCMV activity of novel 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine 5, an isostere of PMEG monoethyl ester, are described. It has been demonstrated that phosphonate 5 showed comparable or greater anti-HCMV activity than ganciclovir against the AD-169 and Davis strains in tissue culture.

Original language	English
Pages (from-to)	2241-2244
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	4
Issue number	18
DOIs	https://doi.org/10.1016/S0960-894X(00)80078-5
State	Published - 22 Sep 1994

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title = "Synthesis and anti-HCMV activity of 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine, an isostere of PMEG monoethyl ester",

abstract = "The synthesis and anti-HCMV activity of novel 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine 5, an isostere of PMEG monoethyl ester, are described. It has been demonstrated that phosphonate 5 showed comparable or greater anti-HCMV activity than ganciclovir against the AD-169 and Davis strains in tissue culture.",

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AU - Kim, Young Woo

AU - Kim, Key H.

PY - 1994/9/22

Y1 - 1994/9/22

N2 - The synthesis and anti-HCMV activity of novel 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine 5, an isostere of PMEG monoethyl ester, are described. It has been demonstrated that phosphonate 5 showed comparable or greater anti-HCMV activity than ganciclovir against the AD-169 and Davis strains in tissue culture.

AB - The synthesis and anti-HCMV activity of novel 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine 5, an isostere of PMEG monoethyl ester, are described. It has been demonstrated that phosphonate 5 showed comparable or greater anti-HCMV activity than ganciclovir against the AD-169 and Davis strains in tissue culture.

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U2 - 10.1016/S0960-894X(00)80078-5

DO - 10.1016/S0960-894X(00)80078-5

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SN - 0960-894X

VL - 4

SP - 2241

EP - 2244

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Synthesis and anti-HCMV activity of 9-[[(ethoxyhydroxyphosphinyl)methoxy]methoxy]guanine, an isostere of PMEG monoethyl ester

Abstract

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