Syntheses of all regioisomers of MYO-inositol bisphosphate

Sung Kee Chung, Young Tae Chang, Yong Uk Kwon

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All possible nine regioisomers of myo-inositol bisphosphate were synthesized using various isopropylidene and benzoyl inositol derivatives as intermediates. These intermediates were successfully phosphorylated with diethyl chlorophosphite followed by oxidation. Selective diphosphorylations on several EBz3 intermediates were also examined as possible routes to IP2s. All of the protecting groups were easily removed in a one-pot procedure to give the sodium salts of the title compounds, IP2 regioisomers.

Original languageEnglish
Pages (from-to)369-384
Number of pages16
JournalJournal of Carbohydrate Chemistry
Issue number3
StatePublished - 1998

Bibliographical note

Funding Information:
This work was supported by research grants from the Korea Science and Engineering FoundatiodCenter for Biohnctional Molecules, and the Ministry of EducatiodBasic Science Research Institute Program (343 7-97).


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