@article{172ce484beaa41ad9ed9e6d9963840bc,
title = "Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production",
abstract = "A 28-membered 1,2,3-triazolyl salicylamide library was synthesized via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition and evaluated for their abilities to inhibit NO production in LPS-activated RAW264.7 macrophage cells. Among 28 analogues, 29g showed a significant inhibitory activity (IC 50 = 12.8 μM). The inhibitory effects of 29g on LPS-mediated NO production in macrophage cells appeared to be associated with the suppression of iNOS expression.",
keywords = "Click chemistry, Library, Salicylamide, Triazole, iNOS",
author = "Jieun Yoon and Lan Cho and Lee, {Sang Kook} and Ryu, {Jae Sang}",
note = "Funding Information: This work was supported by the grant from the National Core Research Center program (No. R15-2006-020) of the Ministry of Science & Technology and the Korea Science and Engineering Foundation and the grant from Basic Science Research Program (2009-0075425) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology. J. Yoon was supported by the Brain Korea 21 project. ",
year = "2011",
month = apr,
day = "1",
doi = "10.1016/j.bmcl.2011.02.034",
language = "English",
volume = "21",
pages = "1953--1957",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Ltd.",
number = "7",
}