Syntheses of 1,2,3-triazolyl salicylamides with inhibitory activity on lipopolysaccharide-induced nitric oxide production

Jieun Yoon, Lan Cho, Sang Kook Lee, Jae Sang Ryu

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A 28-membered 1,2,3-triazolyl salicylamide library was synthesized via a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition and evaluated for their abilities to inhibit NO production in LPS-activated RAW264.7 macrophage cells. Among 28 analogues, 29g showed a significant inhibitory activity (IC 50 = 12.8 μM). The inhibitory effects of 29g on LPS-mediated NO production in macrophage cells appeared to be associated with the suppression of iNOS expression.

Original languageEnglish
Pages (from-to)1953-1957
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume21
Issue number7
DOIs
StatePublished - 1 Apr 2011

Keywords

  • Click chemistry
  • iNOS
  • Library
  • Salicylamide
  • Triazole

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