@article{000be9a9673e49c9a4c4afb78377af0f,
title = "Synergistic combination of near-infrared irradiation and targeted gold nanoheaters for enhanced photothermal neural stimulation",
abstract = "Despite a potential of infrared neural stimulation (INS) for modulating neural activities, INS suffers from limited light confinement and bulk tissue heating. Here, a novel methodology for an advanced optical stimulation is proposed by combining near-infrared (NIR) stimulation with gold nanorods (GNRs) targeted to neuronal cell membrane. We confirmed experimentally that in vitro and in vivo neural activation is associated with a local heat generation based on NIR stimulation and GNRs. Compared with the case of NIR stimulation without an aid of GNRs, combination with celltargeted GNRs allows photothermal stimulation with faster neural response, lower delivered energy, higher stimulation efficiency and stronger behavior change. Since the suggested method can reduce a requisite radiant exposure level and alleviate a concern of tissue damage, it is expected to open up new possibilities for applications to optical neuromodulations for diverse excitable tissues and treatments of neurological disorders.",
author = "Kyungsik Eom and Changkyun Im and Seoyoung Hwang and Seyoung Eom and Kim, {Tae Seong} and Jeong, {Hae Sun} and Kim, {Kyung Hwan} and Byun, {Kyung Min} and Jun, {Sang Beom} and Kim, {Sung June}",
note = "Funding Information: This work was supported by the Brain Korea 21 Plus Project, the Department of Electrical and Computer Engineering, Seoul National University in 2015 and by a grant to CABMC (Control of Animal Brain using MEMS Chip) funded by Defense Acquisition Program Administration (UD140069ID). This study was also supported by engineering-dentistry interdisciplinary research grant jointly funded by college of engineering and college of dentistry, Seoul National University, by the National Research Foundation of Korea (NRF) grants funded by the Korea government (MEST), and by CISS as GFP (CISS-2012M3A6A6054204) and NRF- 2014R1A1A1A05003770 Publisher Copyright: {\textcopyright} 2016 Optical Society of America.",
year = "2016",
month = mar,
day = "31",
doi = "10.1364/BOE.7.001614",
language = "English",
volume = "7",
pages = "1614--1625",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "4",
}