Syndecans play dual roles as cell adhesion receptors and docking receptors

Mi Jung Kwon, Bohee Jang, Jae Youn Yi, Inn Oc Han, Eok Soo Oh

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown

Original languageEnglish
Pages (from-to)2207-2211
Number of pages5
JournalFEBS Letters
Issue number16
StatePublished - 30 Jul 2012

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Projects, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A090615 to ESO) and in part by Grant No. R15-2006-020 from the NCRC program of the MEST and the KOSEF through the Center for Cell Signaling and Drug Discovery Research at Ewha Womans University.


  • Adhesion receptor
  • Cell adhesion
  • Docking receptor
  • Extracellular matrix
  • Signal transduction
  • Syndecan


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