Syndecans play dual roles as cell adhesion receptors and docking receptors

Mi Jung Kwon, Bohee Jang, Jae Youn Yi, Inn Oc Han, Eok Soo Oh

Research output: Contribution to journalReview articlepeer-review

37 Scopus citations

Abstract

Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown

Original languageEnglish
Pages (from-to)2207-2211
Number of pages5
JournalFEBS Letters
Volume586
Issue number16
DOIs
StatePublished - 30 Jul 2012

Keywords

  • Adhesion receptor
  • Cell adhesion
  • Docking receptor
  • Extracellular matrix
  • Signal transduction
  • Syndecan

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