Syndecans play dual roles as cell adhesion receptors and docking receptors

Mi Jung Kwon; Bohee Jang; Jae Youn Yi; Inn Oc Han; Eok Soo Oh

doi:10.1016/j.febslet.2012.05.037

Syndecans play dual roles as cell adhesion receptors and docking receptors

Mi Jung Kwon, Bohee Jang, Jae Youn Yi, Inn Oc Han, Eok Soo Oh

Department of Life Science

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown

Original language	English
Pages (from-to)	2207-2211
Number of pages	5
Journal	FEBS Letters
Volume	586
Issue number	16
DOIs	https://doi.org/10.1016/j.febslet.2012.05.037
State	Published - 30 Jul 2012

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Healthcare technology R&D Projects, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A090615 to ESO) and in part by Grant No. R15-2006-020 from the NCRC program of the MEST and the KOSEF through the Center for Cell Signaling and Drug Discovery Research at Ewha Womans University.

Keywords

Adhesion receptor
Cell adhesion
Docking receptor
Extracellular matrix
Signal transduction
Syndecan

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10.1016/j.febslet.2012.05.037

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title = "Syndecans play dual roles as cell adhesion receptors and docking receptors",

abstract = "Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown",

keywords = "Adhesion receptor, Cell adhesion, Docking receptor, Extracellular matrix, Signal transduction, Syndecan",

author = "Kwon, {Mi Jung} and Bohee Jang and Yi, {Jae Youn} and Han, {Inn Oc} and Oh, {Eok Soo}",

note = "Funding Information: This study was supported by a grant of the Korea Healthcare technology R&D Projects, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A090615 to ESO) and in part by Grant No. R15-2006-020 from the NCRC program of the MEST and the KOSEF through the Center for Cell Signaling and Drug Discovery Research at Ewha Womans University.",

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doi = "10.1016/j.febslet.2012.05.037",

language = "English",

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T1 - Syndecans play dual roles as cell adhesion receptors and docking receptors

AU - Kwon, Mi Jung

AU - Jang, Bohee

AU - Yi, Jae Youn

AU - Han, Inn Oc

AU - Oh, Eok Soo

N1 - Funding Information: This study was supported by a grant of the Korea Healthcare technology R&D Projects, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A090615 to ESO) and in part by Grant No. R15-2006-020 from the NCRC program of the MEST and the KOSEF through the Center for Cell Signaling and Drug Discovery Research at Ewha Womans University.

PY - 2012/7/30

Y1 - 2012/7/30

N2 - Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown

AB - Syndecan are a family of cell surface heparan sulfate proteoglycans that act as cell surface receptors. Most cell surface receptors have a limited number and type of ligand interactions, responding only to the binding of (a) specific ligand(s). In contrast, syndecans can interact with various numbers and types of ligands, and thus play more diverse roles than others. Various syndecan functions have not yet been fully classified and categorized, but we herein review previous studies suggesting that syndecans play dual function as cell surface receptors by acting as both adhesion receptors and docking receptors. Through this dual regulatory function, syndecans are capable of regulating both intra- and extracellular activities, potentially altering a variety of cell behaviors. Crown

KW - Adhesion receptor

KW - Cell adhesion

KW - Docking receptor

KW - Extracellular matrix

KW - Signal transduction

KW - Syndecan

UR - http://www.scopus.com/inward/record.url?scp=84864277708&partnerID=8YFLogxK

U2 - 10.1016/j.febslet.2012.05.037

DO - 10.1016/j.febslet.2012.05.037

M3 - Review article

C2 - 22659189

AN - SCOPUS:84864277708

SN - 0014-5793

VL - 586

SP - 2207

EP - 2211

JO - FEBS Letters

JF - FEBS Letters

IS - 16

ER -

Syndecans play dual roles as cell adhesion receptors and docking receptors

Abstract

Bibliographical note

Keywords

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