Syndecan proteoglycans and cell adhesion

Anne Woods, Eok Soo Oh, John R. Couchman

Research output: Contribution to journalShort surveypeer-review

77 Scopus citations

Abstract

It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalMatrix Biology
Volume17
Issue number7
DOIs
StatePublished - Nov 1998

Keywords

  • Cell adhesion
  • Extracellular matrix
  • Microfilaments
  • Protein kinase C
  • Syndecan

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