It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.
Bibliographical noteFunding Information:
We would like to thank colleagues who shared data with us before publication and apologize that, due to space limitations, we could not include more individual citations but have relied heavily on reviews. Parts of this work were supported by NIH grant GM 50194 (JRC) and a Development and Feasibility grant from the Multipurpose Arthritis and Musculoskeletal Diseases Center, UAB, NIH grant AR 20614 (AW).
- Cell adhesion
- Extracellular matrix
- Protein kinase C