Syndecan proteoglycans and cell adhesion

Anne Woods; Eok Soo Oh; John R. Couchman

doi:10.1016/S0945-053X(98)90095-6

Syndecan proteoglycans and cell adhesion

Anne Woods, Eok Soo Oh, John R. Couchman

Department of Life Science

Research output: Contribution to journal › Short survey › peer-review

80 Scopus citations

Abstract

It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

Original language	English
Pages (from-to)	477-483
Number of pages	7
Journal	Matrix Biology
Volume	17
Issue number	7
DOIs	https://doi.org/10.1016/S0945-053X(98)90095-6
State	Published - Nov 1998

Bibliographical note

Funding Information:
We would like to thank colleagues who shared data with us before publication and apologize that, due to space limitations, we could not include more individual citations but have relied heavily on reviews. Parts of this work were supported by NIH grant GM 50194 (JRC) and a Development and Feasibility grant from the Multipurpose Arthritis and Musculoskeletal Diseases Center, UAB, NIH grant AR 20614 (AW).

Keywords

Cell adhesion
Extracellular matrix
Microfilaments
Protein kinase C
Syndecan

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title = "Syndecan proteoglycans and cell adhesion",

abstract = "It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.",

keywords = "Cell adhesion, Extracellular matrix, Microfilaments, Protein kinase C, Syndecan",

author = "Anne Woods and Oh, {Eok Soo} and Couchman, {John R.}",

note = "Funding Information: We would like to thank colleagues who shared data with us before publication and apologize that, due to space limitations, we could not include more individual citations but have relied heavily on reviews. Parts of this work were supported by NIH grant GM 50194 (JRC) and a Development and Feasibility grant from the Multipurpose Arthritis and Musculoskeletal Diseases Center, UAB, NIH grant AR 20614 (AW).",

year = "1998",

month = nov,

doi = "10.1016/S0945-053X(98)90095-6",

language = "English",

volume = "17",

pages = "477--483",

journal = "Matrix Biology",

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TY - JOUR

T1 - Syndecan proteoglycans and cell adhesion

AU - Woods, Anne

AU - Oh, Eok Soo

AU - Couchman, John R.

N1 - Funding Information: We would like to thank colleagues who shared data with us before publication and apologize that, due to space limitations, we could not include more individual citations but have relied heavily on reviews. Parts of this work were supported by NIH grant GM 50194 (JRC) and a Development and Feasibility grant from the Multipurpose Arthritis and Musculoskeletal Diseases Center, UAB, NIH grant AR 20614 (AW).

PY - 1998/11

Y1 - 1998/11

N2 - It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

AB - It is now becoming clear that a family of transmembrane proteoglycans, the syndecans have important roles in cell adhesion. They participate through binding of matrix ligand to their glycosaminoglycan chains, clustering, and the induction of signaling cascades to modify the internal microfilament organization. Syndecans can modulate the type of adhesive responses induced by other matrix ligand-receptor interactions, such as those involving the integrins, and so contribute to the control of cell morphology, adhesion and migration.

KW - Cell adhesion

KW - Extracellular matrix

KW - Microfilaments

KW - Protein kinase C

KW - Syndecan

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U2 - 10.1016/S0945-053X(98)90095-6

DO - 10.1016/S0945-053X(98)90095-6

M3 - Short survey

C2 - 9881599

AN - SCOPUS:0031703639

SN - 0945-053X

VL - 17

SP - 477

EP - 483

JO - Matrix Biology

JF - Matrix Biology

IS - 7

ER -

Syndecan proteoglycans and cell adhesion

Abstract

Bibliographical note

Keywords

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