Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin α2

Sojoong Choi, Yeonhee Kim, Haein Park, Inn Oc Han, Eunkyung Chung, Sung Yul Lee, Yong Bae Kim, Jung Weon Lee, Eok Soo Oh, Jae Youn Yi

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Syndecan-2, a transmembrane heparan sulfate proteoglycan, is known to serve as an adhesion receptor, but details of the regulatory mechanism governing syndecan-2 cell adhesion and migration remain unclear. Here, we examined this regulatory mechanism, showing that overexpression of syndecan-2 enhanced collagen adhesion, cell migration and invasion of normal rat intestinal epithelial cells (RIE1), and increased integrin α2 expression levels. Interestingly, RIE1 cells transfected with either syndecan-2 or integrin α2 showed similar adhesion and migration patterns, and a function-blocking anti-integrin α2 antibody abolished syndecan-2-mediated adhesion and migration. Consistent with these findings, transfection of integrin α2 siRNA diminished syndecan-2-induced cell migration in HCT116 human colon cancer cells. Taken together, these results demonstrate a novel cooperation between syndecan-2 and integrin α2β1 in adhesion-mediated cell migration and invasion. This interactive dynamic might be a possible mechanism underlying the tumorigenic activities of colon cancer cells.

Original languageEnglish
Pages (from-to)231-235
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume384
Issue number2
DOIs
StatePublished - 26 Jun 2009

Keywords

  • Adhesion
  • Colon cancer cell
  • Integrin α2
  • Invasion
  • Migration
  • Syndecan-2

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