Sutureless Transplantation of Amniotic Membrane Using a Visible Light-Curable Protein Bioadhesive for Ocular Surface Reconstruction

Seong Woo Maeng, Tae Yoon Park, Ji Sang Min, Longyu Jin, Kye Il Joo, Woo Chan Park, Hyung Joon Cha

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The conjunctiva is a thin mucous membrane of the eye. Pterygium, a commonly appearing disease on the ocular surface, requires surgery to excise the conjunctiva to prevent visual deterioration. Recently, transplantation of the amniotic membrane (AM), which is the innermost membrane of the placenta, has been highlighted as an efficient method to cure conjunctiva defects because of its advantages of no side effects compared to mitomycin C treatment and not leaving additional scars on donor site compared to conjunctival autografting. However, to minimize additional damage to the ocular surface by suturing, AM transplantation (AMT) needs to be simplified by using a less invasive, time-saving method. In this work, a visible light-curable protein bioadhesive (named FixLight) for efficient sutureless AMT is applied. FixLight, which is based on bioengineered mussel adhesive protein (MAP), is easily applied between damaged ocular surfaces and transplanted AM, and rapidly cured by harmless blue light activation. Through in vivo evaluation using a rabbit model, the authors demonstrated that FixLight enabled facile, fast, and strong attachment of AM on sclera and promoted ocular surface reconstruction with good biocompatibility. Thus, FixLight can be successfully used as a promising clinical bioadhesive in opthalmological surgeries that require sutureless and rapid operation.

Original languageEnglish
Article number2100100
JournalAdvanced Healthcare Materials
Volume10
Issue number13
DOIs
StatePublished - 7 Jul 2021

Keywords

  • amniotic membrane transplantations
  • conjunctivas
  • mussel adhesive proteins
  • ocular surface reconstructions
  • visible light-curable bioadhesives

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