@article{e0034623aedf49d3a56448390fcc6f47,
title = "Sutureless full-thickness skin grafting using a dual drug-in-bioadhesive coacervate",
abstract = "Conventional skin grafting procedures such as suturing and stapling are accompanied by pathologic scarring with functional and psychological sequelae; severe scars need a prolonged recovery period, increasing the chance of wound infections or graft contraction. The present study develops a novel bioadhesive delivering dual drugs to minimize scar formation and accelerate wound healing during full-thickness skin grafting. The bioadhesive is prepared via coacervation of a mussel protein and shows high adhesive strength in both porcine skin and in vivo rodent models; furthermore, it sustainably releases dual drugs (allantoin and epithelial growth factor) to enhance re-epithelialization and collagen deposition while simultaneously reducing scar formation. The proposed dual-drug-in-bioadhesive coacervate may ideally meet the requirements of the wound healing process and is a promising candidate for sutureless full-thickness skin grafting.",
keywords = "Complex coacervate, Dual drug-in-bioadhesive, Full-thickness skin grafting, Mussel adhesive protein, Wound healing process",
author = "Park, {Woo Hyung} and Jaeyun Lee and Kim, {Hyo Jeong} and Joo, {Kye Il} and Cha, {Hyung Joon}",
note = "Funding Information: We acknowledge the financial support by the Korea Health Technology R&D Project (grant number: HI20C0090, to H.J.C.) through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare, Korea and the Korea Research Institute of Chemical Technology through Core Program (grant number: SS2242-10, to H.J.K.). We also thank Nature Gluetech Co., LTD for providing the bioengineered MAP. Funding Information: We acknowledge the financial support by the Korea Health Technology R&D Project (grant number: HI20C0090, to H.J.C.) through the Korea Health Industry Development Institute funded by the Ministry of Health and Welfare, Korea and the Korea Research Institute of Chemical Technology through Core Program (grant number: SS2242-10, to H.J.K.). We also thank Nature Gluetech Co. LTD for providing the bioengineered MAP. Publisher Copyright: {\textcopyright} 2022 Elsevier B.V.",
year = "2022",
month = oct,
day = "15",
doi = "10.1016/j.cej.2022.137272",
language = "English",
volume = "446",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier",
}