Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism

Na Yeon Jung, Kee Hyung Park, Sang Won Seo, Hee Jin Kim, Jee Hoon Roh, Jae Hong Lee, Kyung Won Park, Jay C. Kwon, Jee Hyang Jeong, Soo Jin Yoon, Byeong C. Kim, Young Ho Park, Sangyun Kim, Jae Won Jang, Young Chul Youn, Dong Won Yang, Seong Hye Choi, Duk L. Na, Eun Joo Kim

Research output: Contribution to journalArticlepeer-review


We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.

Original languageEnglish
Article number2260
JournalJournal of Clinical Medicine
Issue number8
StatePublished - 1 Apr 2022

Bibliographical note

Funding Information:
Funding: This research was supported by the “National Institute of Health” research project (project No.2021-ER1004-01); a 2020 research grant from Pusan National University Yangsan Hospital; a grant from the Brain Convergence Research Program of the National Research Foundation, funded by the Ministry of Science and ICT, Republic of Korea (NRF-2020M3E5D2A01084721).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • abnormal behavior
  • frontotemporal dementia
  • parkinsonism
  • survival


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