Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism

Na Yeon Jung; Kee Hyung Park; Sang Won Seo; Hee Jin Kim; Jee Hoon Roh; Jae Hong Lee; Kyung Won Park; Jay C. Kwon; Jee Hyang Jeong; Soo Jin Yoon; Byeong C. Kim; Young Ho Park; Sangyun Kim; Jae Won Jang; Young Chul Youn; Dong Won Yang; Seong Hye Choi; Duk L. Na; Eun Joo Kim

doi:10.3390/jcm11082260

Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism

Na Yeon Jung, Kee Hyung Park, Sang Won Seo, Hee Jin Kim, Jee Hoon Roh, Jae Hong Lee, Kyung Won Park, Jay C. Kwon, Jee Hyang Jeong, Soo Jin Yoon, Byeong C. Kim, Young Ho Park, Sangyun Kim, Jae Won Jang, Young Chul Youn, Dong Won Yang, Seong Hye Choi, Duk L. Na, Eun Joo Kim

Department of Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.

Original language	English
Article number	2260
Journal	Journal of Clinical Medicine
Volume	11
Issue number	8
DOIs	https://doi.org/10.3390/jcm11082260
State	Published - 1 Apr 2022

Bibliographical note

Funding Information:
Funding: This research was supported by the “National Institute of Health” research project (project No.2021-ER1004-01); a 2020 research grant from Pusan National University Yangsan Hospital; a grant from the Brain Convergence Research Program of the National Research Foundation, funded by the Ministry of Science and ICT, Republic of Korea (NRF-2020M3E5D2A01084721).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

abnormal behavior
frontotemporal dementia
parkinsonism
survival

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10.3390/jcm11082260

Cite this

Jung, N. Y., Park, K. H., Seo, S. W., Kim, H. J., Roh, J. H., Lee, J. H., Park, K. W., Kwon, J. C., Jeong, J. H., Yoon, S. J., Kim, B. C., Park, Y. H., Kim, S., Jang, J. W., Youn, Y. C., Yang, D. W., Choi, S. H., Na, D. L., & Kim, E. J. (2022). Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism. Journal of Clinical Medicine, 11(8), Article 2260. https://doi.org/10.3390/jcm11082260

@article{028cce75effb470b8f4a4eeecd351b47,

title = "Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism",

abstract = "We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson{\textquoteright}s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.",

keywords = "abnormal behavior, frontotemporal dementia, parkinsonism, survival",

author = "Jung, {Na Yeon} and Park, {Kee Hyung} and Seo, {Sang Won} and Kim, {Hee Jin} and Roh, {Jee Hoon} and Lee, {Jae Hong} and Park, {Kyung Won} and Kwon, {Jay C.} and Jeong, {Jee Hyang} and Yoon, {Soo Jin} and Kim, {Byeong C.} and Park, {Young Ho} and Sangyun Kim and Jang, {Jae Won} and Youn, {Young Chul} and Yang, {Dong Won} and Choi, {Seong Hye} and Na, {Duk L.} and Kim, {Eun Joo}",

note = "Funding Information: Funding: This research was supported by the “National Institute of Health” research project (project No.2021-ER1004-01); a 2020 research grant from Pusan National University Yangsan Hospital; a grant from the Brain Convergence Research Program of the National Research Foundation, funded by the Ministry of Science and ICT, Republic of Korea (NRF-2020M3E5D2A01084721). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = apr,

day = "1",

doi = "10.3390/jcm11082260",

language = "English",

volume = "11",

journal = "Journal of Clinical Medicine",

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Jung, NY, Park, KH, Seo, SW, Kim, HJ, Roh, JH, Lee, JH, Park, KW, Kwon, JC, Jeong, JH, Yoon, SJ, Kim, BC, Park, YH, Kim, S, Jang, JW, Youn, YC, Yang, DW, Choi, SH, Na, DL & Kim, EJ 2022, 'Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism', Journal of Clinical Medicine, vol. 11, no. 8, 2260. https://doi.org/10.3390/jcm11082260

TY - JOUR

T1 - Survival in Korean Patients with Frontotemporal Dementia Syndrome

T2 - Association with Behavioral Features and Parkinsonism

AU - Jung, Na Yeon

AU - Park, Kee Hyung

AU - Seo, Sang Won

AU - Kim, Hee Jin

AU - Roh, Jee Hoon

AU - Lee, Jae Hong

AU - Park, Kyung Won

AU - Kwon, Jay C.

AU - Jeong, Jee Hyang

AU - Yoon, Soo Jin

AU - Kim, Byeong C.

AU - Park, Young Ho

AU - Kim, Sangyun

AU - Jang, Jae Won

AU - Youn, Young Chul

AU - Yang, Dong Won

AU - Choi, Seong Hye

AU - Na, Duk L.

AU - Kim, Eun Joo

N1 - Funding Information: Funding: This research was supported by the “National Institute of Health” research project (project No.2021-ER1004-01); a 2020 research grant from Pusan National University Yangsan Hospital; a grant from the Brain Convergence Research Program of the National Research Foundation, funded by the Ministry of Science and ICT, Republic of Korea (NRF-2020M3E5D2A01084721). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022/4/1

Y1 - 2022/4/1

N2 - We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.

AB - We investigated the survival time of each clinical syndrome of frontotemporal dementia (FTD) and the impacts of behavioral and motor features on survival of FTD. A total of 216 patients with FTD [82 behavioral variant FTD (bvFTD), 78 semantic variant primary progressive aphasia (svPPA), 43 non-fluent/agrammatic variant PPA (nfvPPA), 13 FTD-motor neuron disease (MND)] were enrolled from 16 centers across Korea. Behaviors and parkinsonism were assessed using the Frontal Behavioral Inventory and Unified Parkinson’s Disease Rating Scale Part III, respectively. The Kaplan–Meier method was used for the survival analysis and the Cox proportional hazards model was applied for analysis of the effect of behavioral and motor symptoms on survival, after controlling vascular risk factors and cancer. An overall median survival of FTD was 12.1 years. The survival time from onset was shortest for FTD-MND and longest for svPPA. The median survival time of patients with bvFTD was unavailable but likely comparable to that of patients with nfvPPA. In the bvFTD group, negative behavioral symptoms and akinetic rigidity were significantly associated with survival. In the nfvPPA group, the presence of dysarthria had a negative impact on survival. These findings provide useful information to clinicians planning for care.

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KW - frontotemporal dementia

KW - parkinsonism

KW - survival

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U2 - 10.3390/jcm11082260

DO - 10.3390/jcm11082260

M3 - Article

AN - SCOPUS:85128393828

SN - 2077-0383

VL - 11

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

IS - 8

M1 - 2260

ER -

Survival in Korean Patients with Frontotemporal Dementia Syndrome: Association with Behavioral Features and Parkinsonism

Abstract

Bibliographical note

Keywords

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