Surveillance of contrast-media-induced hypersensitivity reactions using signals from an electronic medical recording system

Min Hye Kim, Chang Han Park, Duk In Kim, Kyung Mook Kim, Hui Kyu Kim, Kyu Hyoung Lim, Woo Jung Song, Sang Min Lee, Sae Hoon Kim, Hyouk Soo Kwon, Heung Woo Park, Chang Jin Yoon, Sang Heon Cho, Kyung Up Min, You Young Kim, Yoon Seok Chang

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Background: Contrast-media (CM) hypersensitivity is a well-known adverse drug reaction. Surveillance of adverse drug reactions usually depends on spontaneous reports. However, the rate of spontaneous reports is low. Recent progress in information technology enables the electronic search on signals of adverse drug reactions from electronic medical recording (EMR) systems. Objectives: To analyze the incidence and clinical characteristics of CM hypersensitivity using an EMR-based surveillance system. Methods: The surveillance system used signals from standardized terms within the international classification of nursing practice terms that can indicate symptoms of CM hypersensitivity and from the order codes for procedures that used contrast media, antihistamine, and epinephrine. The search strategy was validated by allergists comparing the electronic search strategy versus manually reviewing medical charts over one month. The main study covered for one year period. Results: Detection rate of the electronic search method was 0.9% (7/759), while that of the manual search method was 0.8% (6/759). EMR-based electronic search method was highly efficient: reduced the charts that needed to be reviewed by 96% (28/759). The sensitivity of electronic screening was 66.7%, specificity was 99.6%, and the negative predictive value was 99.7%. CM hypersensitivity reactions were noted in 266 among 12,483 cases (2.1%). Urticaria was the most frequent symptom (74.4%). CT was the most frequent procedure (3.6%) that induced CM hypersensitivity. Conclusion: A surveillance system using EMR may be a useful tool in the study of drug hypersensitivity epidemiology and may be used in an adverse drug reaction alarm system and as a clinical, decision making support system.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalAnnals of Allergy, Asthma and Immunology
Issue number3
StatePublished - Mar 2012

Bibliographical note

Funding Information:
Funding Sources: This study was supported by a grant ( A030001 ) from the Korean Health 21 R&D Project, Ministry of Health & Welfare and Family Affairs , Republic of Korea and a grant ( 09182KFDA889 ) from the Korea Food & Drug Administration in 2011.


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