TY - JOUR
T1 - Surface-imprinted, thermosensitive, core-shell nanosphere for molecular recognition
AU - Ko, Du Young
AU - Lee, Hwa Jeong
AU - Jeong, Byeongmoon
PY - 2006/8/23
Y1 - 2006/8/23
N2 - The D-glucose imprinted core-shell nanosphere with an average size of ≈60 to 80 nm showed a significant preference for the binding of D-glucose than the non-imprinted core-shell nanosphere. Depending on temperature, the binding site in the shell with N-isopropylacrylamide oligomer underwent a significant change in binding affinity. In addition, the D-glucose imprinted core-shell nanosphere showed a two times higher affinity for D-glucose than L-glucose, suggesting chiral recognition of the binding site. The core-shell nanosphere reported here is a good biomimetic model system with a well-defined morphology, high surface area, and variable binding affinity through a change in temperature.
AB - The D-glucose imprinted core-shell nanosphere with an average size of ≈60 to 80 nm showed a significant preference for the binding of D-glucose than the non-imprinted core-shell nanosphere. Depending on temperature, the binding site in the shell with N-isopropylacrylamide oligomer underwent a significant change in binding affinity. In addition, the D-glucose imprinted core-shell nanosphere showed a two times higher affinity for D-glucose than L-glucose, suggesting chiral recognition of the binding site. The core-shell nanosphere reported here is a good biomimetic model system with a well-defined morphology, high surface area, and variable binding affinity through a change in temperature.
KW - Core-shell nanosphere
KW - Molecular recognition
KW - Surface imprint
KW - Thermosensitive polymer
UR - http://www.scopus.com/inward/record.url?scp=33748577663&partnerID=8YFLogxK
U2 - 10.1002/marc.200600259
DO - 10.1002/marc.200600259
M3 - Article
AN - SCOPUS:33748577663
SN - 1022-1336
VL - 27
SP - 1367
EP - 1372
JO - Macromolecular Rapid Communications
JF - Macromolecular Rapid Communications
IS - 16
ER -