@article{487fd4ac4fbc47a2bb8f1dc0a41847d7,
title = "Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy",
abstract = "Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.",
keywords = "nanostructures, photoacoustic imaging, photothermal therapy, phthalocyanine, supramolecular chemistry",
author = "Xingshu Li and Park, {Eun Yeong} and Youngnam Kang and Nahyun Kwon and Mengyao Yang and Seunghyun Lee and Kim, {Won Jong} and Chulhong Kim and Juyoung Yoon",
note = "Funding Information: J.Y. is thankful for financial support from the National Research Foundation of Korea (NRF), which is funded by the Korea government (MSIP) (No. 2012R1A3A2048814). C.K. is thankful for financial support from the National Research Foundation of Korea(NRF), which is funded by the Korea government (MSIT) (No. NRF-2019R1A2C2006269). W.J.K. is thankful for financial support from the Creative Materials Discovery Program through the National Research Foundation (NFR) funded by Ministry of Science and ICT (NRF-2018M3D1A1058813). We would like to thank Prof. Woo-Dong Jang at Yonsei University for providing valuable feedback. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2020",
month = may,
day = "25",
doi = "10.1002/anie.201916147",
language = "English",
volume = "59",
pages = "8630--8634",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "22",
}