Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy

Xingshu Li, Eun Yeong Park, Youngnam Kang, Nahyun Kwon, Mengyao Yang, Seunghyun Lee, Won Jong Kim, Chulhong Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.

Original languageEnglish
Pages (from-to)8630-8634
Number of pages5
JournalAngewandte Chemie - International Edition
Volume59
Issue number22
DOIs
StatePublished - 25 May 2020

Keywords

  • nanostructures
  • photoacoustic imaging
  • photothermal therapy
  • phthalocyanine
  • supramolecular chemistry

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