TY - JOUR
T1 - Supramolecular Phthalocyanine Assemblies for Improved Photoacoustic Imaging and Photothermal Therapy
AU - Li, Xingshu
AU - Park, Eun Yeong
AU - Kang, Youngnam
AU - Kwon, Nahyun
AU - Yang, Mengyao
AU - Lee, Seunghyun
AU - Kim, Won Jong
AU - Kim, Chulhong
AU - Yoon, Juyoung
N1 - Publisher Copyright:
© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2020/5/25
Y1 - 2020/5/25
N2 - Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.
AB - Phototheranostic nanoplatforms are of particular interest for cancer diagnosis and imaging-guided therapy. Herein, we develop a supramolecular approach to fabricate a nanostructured phototheranostic agent through the direct self-assembly of two water-soluble phthalocyanine derivatives, PcS4 and PcN4. The nature of the molecular recognition between PcS4 and PcN4 facilitates the formation of nanostructure (PcS4-PcN4) and consequently enables the fabrication of PcS4-PcN4 with completely quenched fluorescence and reduced singlet oxygen generation, leading to the high photoacoustic and photothermal activity of PcS4-PcN4. In vivo evaluations suggest that PcS4-PcN4 could not only efficiently visualize a tumor with high contrast through whole-body photoacoustic imaging but also enable excellent photothermal therapy for cancer.
KW - nanostructures
KW - photoacoustic imaging
KW - photothermal therapy
KW - phthalocyanine
KW - supramolecular chemistry
UR - http://www.scopus.com/inward/record.url?scp=85081951611&partnerID=8YFLogxK
U2 - 10.1002/anie.201916147
DO - 10.1002/anie.201916147
M3 - Article
C2 - 32077201
AN - SCOPUS:85081951611
SN - 1433-7851
VL - 59
SP - 8630
EP - 8634
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 22
ER -