TY - JOUR
T1 - Supramolecular Nanozyme-Based Cancer Catalytic Therapy
AU - Han, Jingjing
AU - Yoon, Juyoung
N1 - Funding Information:
This study was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP) (No. 2012R1A3A2048814).
Publisher Copyright:
©
PY - 2020/11/16
Y1 - 2020/11/16
N2 - The nanozyme concept appeals to numerous scientists with interest in cancer catalytic therapy based on an easy and economic preparation with highly catalytic and stable properties compared to a natural enzyme. The supramolecular nanozyme is an especially efficient and simple method, which has been successful in biomedical applications by changing the redox state and reactive oxygen species in a cancer environment. Representative examples of nanozymes and supramolecular nanozymes in cancer catalytic therapy with respect to construction and development are displayed in this review. Emphasis is also placed on the supramolecular nanozyme materials and the inherent structure of those containing nanoparticles, hydrogels, nanovesicles, and the catalytic mechanism and reaction. The supramolecular nanozyme, promising for its special properties of selectivity, high catalytic capability and stability, could reveal the mysterious properties of the enzyme itself, and the efficient inhibition of the signaling channel in cancer catalytic therapy.
AB - The nanozyme concept appeals to numerous scientists with interest in cancer catalytic therapy based on an easy and economic preparation with highly catalytic and stable properties compared to a natural enzyme. The supramolecular nanozyme is an especially efficient and simple method, which has been successful in biomedical applications by changing the redox state and reactive oxygen species in a cancer environment. Representative examples of nanozymes and supramolecular nanozymes in cancer catalytic therapy with respect to construction and development are displayed in this review. Emphasis is also placed on the supramolecular nanozyme materials and the inherent structure of those containing nanoparticles, hydrogels, nanovesicles, and the catalytic mechanism and reaction. The supramolecular nanozyme, promising for its special properties of selectivity, high catalytic capability and stability, could reveal the mysterious properties of the enzyme itself, and the efficient inhibition of the signaling channel in cancer catalytic therapy.
KW - cancer catalytic therapy
KW - nanozyme
KW - reactive oxygen species
KW - redox state
KW - supramolecular assembly
UR - http://www.scopus.com/inward/record.url?scp=85096106627&partnerID=8YFLogxK
U2 - 10.1021/acsabm.0c01127
DO - 10.1021/acsabm.0c01127
M3 - Article
AN - SCOPUS:85096106627
SN - 2576-6422
VL - 3
SP - 7344
EP - 7351
JO - ACS Applied Bio Materials
JF - ACS Applied Bio Materials
IS - 11
ER -