Suppression of TPA-induced tumor cell invasion by sulfuretin via inhibition of NF-κB-dependent MMP-9 expression

Jeong Mi Kim, Eun Mi Noh, Kang Beom Kwon, Jong Suk Kim, Yong Ouk You, Jin Ki Hwang, Bo Mi Hwang, Min Seuk Kim, Seung Jin Lee, Sung Hoo Jung, Hyun Jo Youn, Eun Yong Chung, Young Rae Lee

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Cell invasion is required for neoplastic metastasis. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in the process of cancer cell invasion. Sulfuretin is one of the major flavonoids isolated from Rhus verniciflua. Sulfuretin has been used to reduce oxidative stress, platelet aggregation, the inflammatory response and mutagenesis. However, the effect of sulfuretin on breast cancer metastasis is unknown. In this study, we investigated the inhibitory effect of sulfuretin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Sulfuretin inhibited TPA-induced transcriptional activation of nuclear factor-κB (NF-κB). We demonstrated that sulfuretin mediated the inhibition of TPA-induced MMP-9 expression and that cell invasion in MCF-7 cells involved suppression of the NF-κB pathway. Therefore, inhibiting MMP-9 expression by sulfuretin may have therapeutic potential for controlling breast cancer invasiveness.

Original languageEnglish
Pages (from-to)1231-1237
Number of pages7
JournalOncology Reports
Volume29
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Invasion
  • MCF-7
  • MMP-9
  • NF-κB
  • Sulfuretin

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