Suppression of inflammatory cytokine production by ar-turmerone isolated from Curcuma phaeocaulis

Sera Oh, A. Rheum Han, Hye Ryeon Park, Eun Jung Jang, Hyo Kyeong Kim, Mi Gyeong Jeong, Hyuna Song, Gun Hwa Park, Eun Kyoung Seo, Eun Sook Hwang

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26 Scopus citations

Abstract

Rhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti-inflammatory properties are a result of cyclooxygenase-2 inhibition; however, its effect on the T-cell function remains to be elucidated. In this study, four known sesquiterpenoids, viz., ar-turmerone (TM), germacrone (GM), (+)-(4S,5S)-germacrone-4,5-epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4+ T-cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4+ T cells, TM suppressed the interferon (IFN)-γ production, without affecting the interleukin (IL)-4 expression. TM also decreased the expression of IL-2 in CD4+ T cells, but did not change their cell-division rates upon stimulation. These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti-inflammatory effects via suppression of the inflammatory cytokines IFN-γ and IL-2.

Original languageEnglish
Pages (from-to)1034-1041
Number of pages8
JournalChemistry and Biodiversity
Volume11
Issue number7
DOIs
StatePublished - Jul 2014

Keywords

  • Anti-inflammatory activity
  • Curcuma phaeocaulis
  • IFN-γ
  • IL-2
  • Rhizomes
  • ar-Turmerone

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