Supplementation of a polyphenol extract from Ecklonia cava reduces body fat, oxidative and inflammatory stress in overweight healthy subjects with abdominal obesity: A randomized, placebo-controlled, double-blind trial

Hyo Jin Lee, Oran Kwon, Ji Yeon Kim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

A randomized, placebo-controlled, double-blind trial was conducted using subjects with a body mass index over 25 kg/m2 and under 30 kg/m2. Eighty subjects were randomly assigned to receive either a placebo or Ecklonia cava extract (Seapolynol, 360 mg/day) for 12 weeks. In response to Seapolynol consumption, the body fat was significantly reduced from the baseline value. In the abdominal obesity subgroup, Seapolynol group presented with a significant decrease in total adipose tissue area, percent body fat and fat/lean mass ratio and an increase in skeletal muscle index. The oxidized low-density lipoprotein levels and endogenous antioxidant enzyme activities were significantly affected by Seapolynol supplementation. In addition, Seapolynol supplementation significantly increased the mRNA expression of lipid oxidation-related genes and decreased the expression of lipid synthesis-related genes. Inflammatory markers were also reduced by Seapolynol supplementation. In conclusion, Seapolynol may exert beneficial effects on obesity and related metabolic disorders in overweight and obese individuals.

Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalJournal of Functional Foods
Volume46
DOIs
StatePublished - Jul 2018

Keywords

  • Ecklonia cava extract
  • Inflammatory stress
  • Obesity
  • Oxidative stress
  • Polyphenol

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