Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Ji Ting Hou, Nahyun Kwon, Shan Wang, Bingya Wang, Xiaojun He, Juyoung Yoon, Jianliang Shen

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.

Original languageEnglish
Article number214232
JournalCoordination Chemistry Reviews
StatePublished - 1 Jan 2022


  • Bioimaging
  • Hypochlorous acid/hypochlorite
  • Reaction mechanism
  • Reactive oxygen species
  • Sulfur-based fluorescent sensors


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