TY - JOUR
T1 - Sulfur-based fluorescent probes for HOCl
T2 - Mechanisms, design, and applications
AU - Hou, Ji Ting
AU - Kwon, Nahyun
AU - Wang, Shan
AU - Wang, Bingya
AU - He, Xiaojun
AU - Yoon, Juyoung
AU - Shen, Jianliang
N1 - Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science
Funding Information:
Research Program through the National Research Foundation of Korea (NRF) funded by the
Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science, Research Program through the National Research Foundation of Korea (NRF) funded by the, Ministry of Education (2021R1A6A1A10039823).
Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.
AB - Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.
KW - Bioimaging
KW - Hypochlorous acid/hypochlorite
KW - Reaction mechanism
KW - Reactive oxygen species
KW - Sulfur-based fluorescent sensors
UR - http://www.scopus.com/inward/record.url?scp=85116610170&partnerID=8YFLogxK
U2 - 10.1016/j.ccr.2021.214232
DO - 10.1016/j.ccr.2021.214232
M3 - Review article
AN - SCOPUS:85116610170
SN - 0010-8545
VL - 450
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
M1 - 214232
ER -