Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Ji Ting Hou; Nahyun Kwon; Shan Wang; Bingya Wang; Xiaojun He; Juyoung Yoon; Jianliang Shen

doi:10.1016/j.ccr.2021.214232

Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Ji Ting Hou, Nahyun Kwon, Shan Wang, Bingya Wang, Xiaojun He, Juyoung Yoon, Jianliang Shen

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Review article › peer-review

125 Scopus citations

Abstract

Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.

Original language	English
Article number	214232
Journal	Coordination Chemistry Reviews
Volume	450
DOIs	https://doi.org/10.1016/j.ccr.2021.214232
State	Published - 1 Jan 2022

Bibliographical note

Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science

Funding Information:
Research Program through the National Research Foundation of Korea (NRF) funded by the

Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science, Research Program through the National Research Foundation of Korea (NRF) funded by the, Ministry of Education (2021R1A6A1A10039823).

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

Bioimaging
Hypochlorous acid/hypochlorite
Reaction mechanism
Reactive oxygen species
Sulfur-based fluorescent sensors

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10.1016/j.ccr.2021.214232

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title = "Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications",

abstract = "Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.",

keywords = "Bioimaging, Hypochlorous acid/hypochlorite, Reaction mechanism, Reactive oxygen species, Sulfur-based fluorescent sensors",

author = "Hou, {Ji Ting} and Nahyun Kwon and Shan Wang and Bingya Wang and Xiaojun He and Juyoung Yoon and Jianliang Shen",

note = "Funding Information: J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science Funding Information: Research Program through the National Research Foundation of Korea (NRF) funded by the Funding Information: J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science, Research Program through the National Research Foundation of Korea (NRF) funded by the, Ministry of Education (2021R1A6A1A10039823). Publisher Copyright: {\textcopyright} 2021 Elsevier B.V.",

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AU - He, Xiaojun

AU - Yoon, Juyoung

AU - Shen, Jianliang

N1 - Funding Information: J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science Funding Information: Research Program through the National Research Foundation of Korea (NRF) funded by the Funding Information: J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science, Research Program through the National Research Foundation of Korea (NRF) funded by the, Ministry of Education (2021R1A6A1A10039823). Publisher Copyright: © 2021 Elsevier B.V.

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N2 - Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.

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VL - 450

JO - Coordination Chemistry Reviews

JF - Coordination Chemistry Reviews

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ER -

Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Abstract

Bibliographical note

Keywords

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