Sulfur-based fluorescent probes for HOCl: Mechanisms, design, and applications

Ji Ting Hou, Nahyun Kwon, Shan Wang, Bingya Wang, Xiaojun He, Juyoung Yoon, Jianliang Shen

Research output: Contribution to journalReview articlepeer-review

108 Scopus citations

Abstract

Hypochlorous acid (HOCl) is an endogenously produced reactive oxygen species (ROS), which acts as a protector against microbes. However, its aberrant production is implicated in various oxidative-stress related pathophysiological processes, such as cardiovascular disorders, arthritis, and neurodegenerative diseases. Therefore, the direct, rapid, sensitive, and selective detection of endogenous HOCl in living systems is of essential importance for better understanding the HOCl-involved chemical biology. In the last two decades, sulfur-based fluorescent probes for HOCl have been widely designed and they usually show rapid reaction rate, high selectivity and excellent sensitivity. This review summarized the advances that have been made in the development of sulfur-based fluorescent probes for HOCl, and their reaction mechanisms were emphatically discussed. Lastly, the achievements, challenges, and perspectives in this field were outlooked.

Original languageEnglish
Article number214232
JournalCoordination Chemistry Reviews
Volume450
DOIs
StatePublished - 1 Jan 2022

Bibliographical note

Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science

Funding Information:
Research Program through the National Research Foundation of Korea (NRF) funded by the

Funding Information:
J.-T. Hou acknowledges grants from the National Natural Science Foundation of China (no. 21807029). J. Shen thanks the funding support from the National Natural Science Foundation of China (31800833 and 21977081), Zhejiang Provincial Natural Science of Foundation of China (LZ19H180001), Wenzhou Medical University (KYYW201901), University of Chinese Academy of Science (WIBEZD2017001-03). J. Yoon thanks to the support from Basic Science, Research Program through the National Research Foundation of Korea (NRF) funded by the, Ministry of Education (2021R1A6A1A10039823).

Publisher Copyright:
© 2021 Elsevier B.V.

Keywords

  • Bioimaging
  • Hypochlorous acid/hypochlorite
  • Reaction mechanism
  • Reactive oxygen species
  • Sulfur-based fluorescent sensors

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