Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements

Jungwon Huh, Yeung Chul Mun, Eun Sun Yoo, Chu Myong Seong, Wha Soon Chung

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

We report three patients with normal karyotype (NK) ALL, who showed genetic aberrations as determined by high-resolution single nucleotide polymorphism array (SNP-A) analysis at both diagnosis and relapse. We evaluated the clinical relevance of the SNP-A assay for the detection of subtle changes in the size of affected genetic lesions at relapse as well as the prognostic value of the assay. In our patients, application of the SNP-A assay enabled sensitive detection of cryptic changes affecting clinically important genes in NK ALL. Therefore, this assay seems to be more advantageous compared to other conventional methods such as FISH assay, HemaVision (DNA Technology, Denmark), and conventional karyotyping for the detection of an "unstable genotype" at relapse, which may be associated with microscopic clonal evolution and poor prognosis. Further comprehensive studies are required to confirm the issues presented by our case patients in this report.

Original languageEnglish
Pages (from-to)128-131
Number of pages4
JournalAnnals of Laboratory Medicine
Volume35
Issue number1
DOIs
StatePublished - 2015

Keywords

  • Acute lymphoblastic leukemia
  • Array
  • Clonal evolution
  • Normal karyotype
  • Prognosis
  • Single nucleotide polymorphism

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