Submicron-scale topographical control of cell growth using holographic surface relief grating

Hyoungwon Baac, Jeong Hyun Lee, Jong Mo Seo, Tai Hyun Park, Hum Chung, Sin Doo Lee, Sung June Kim

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo- responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.

Original languageEnglish
Pages (from-to)209-212
Number of pages4
JournalMaterials Science and Engineering C
Volume24
Issue number1-2
DOIs
StatePublished - 5 Jan 2004

Bibliographical note

Funding Information:
This work was supported partly by Overhead Research Fund of S.N.U. and also partly by KOSEF through the Nano-Bioelectronics and Systems Research Center at Seoul National University. One of the authors (SDL) acknowledges the support from KOSEF through CFRM at Korea University.

Keywords

  • Cell attachment
  • Cell orientation
  • Holography
  • Photo-responsive polymer
  • Surface relief grating
  • Topographical control

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