Submicron-scale topographical control of cell growth using holographic surface relief grating

Hyoungwon Baac; Jeong Hyun Lee; Jong Mo Seo; Tai Hyun Park; Hum Chung; Sin Doo Lee; Sung June Kim

doi:10.1016/j.msec.2003.09.009

Submicron-scale topographical control of cell growth using holographic surface relief grating

Hyoungwon Baac, Jeong Hyun Lee, Jong Mo Seo, Tai Hyun Park, Hum Chung, Sin Doo Lee, Sung June Kim

Department of Nutritional Science & Food Management

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo- responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.

Original language	English
Pages (from-to)	209-212
Number of pages	4
Journal	Materials Science and Engineering C
Volume	24
Issue number	1-2
DOIs	https://doi.org/10.1016/j.msec.2003.09.009
State	Published - 5 Jan 2004

Bibliographical note

Funding Information:
This work was supported partly by Overhead Research Fund of S.N.U. and also partly by KOSEF through the Nano-Bioelectronics and Systems Research Center at Seoul National University. One of the authors (SDL) acknowledges the support from KOSEF through CFRM at Korea University.

Keywords

Cell attachment
Cell orientation
Holography
Photo-responsive polymer
Surface relief grating
Topographical control

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10.1016/j.msec.2003.09.009

Cite this

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title = "Submicron-scale topographical control of cell growth using holographic surface relief grating",

abstract = "The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo- responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.",

keywords = "Cell attachment, Cell orientation, Holography, Photo-responsive polymer, Surface relief grating, Topographical control",

author = "Hyoungwon Baac and Lee, {Jeong Hyun} and Seo, {Jong Mo} and Park, {Tai Hyun} and Hum Chung and Lee, {Sin Doo} and Kim, {Sung June}",

note = "Funding Information: This work was supported partly by Overhead Research Fund of S.N.U. and also partly by KOSEF through the Nano-Bioelectronics and Systems Research Center at Seoul National University. One of the authors (SDL) acknowledges the support from KOSEF through CFRM at Korea University.",

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doi = "10.1016/j.msec.2003.09.009",

language = "English",

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AU - Baac, Hyoungwon

AU - Lee, Jeong Hyun

AU - Seo, Jong Mo

AU - Park, Tai Hyun

AU - Chung, Hum

AU - Lee, Sin Doo

AU - Kim, Sung June

N1 - Funding Information: This work was supported partly by Overhead Research Fund of S.N.U. and also partly by KOSEF through the Nano-Bioelectronics and Systems Research Center at Seoul National University. One of the authors (SDL) acknowledges the support from KOSEF through CFRM at Korea University.

PY - 2004/1/5

Y1 - 2004/1/5

N2 - The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo- responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.

AB - The cell orientation and attachment were controlled by a submicron-scale topographical cue. For achieving the submicron undulation of surface topography, the laser holography on a photo- responsive azobenzene copolymer layer has been employed to produce surface relief grating (SRG) which has a regular sinusoidal shape. Cultured human astrocytes (HA) were preferentially attached onto the SRG surface and highly elongated along the SRG direction. This topographical control scheme would be very efficient to control the cell growth for cellular engineering applications and to understand the interactions of the cells with a submicron-scale topographical surface.

KW - Cell attachment

KW - Cell orientation

KW - Holography

KW - Photo-responsive polymer

KW - Surface relief grating

KW - Topographical control

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DO - 10.1016/j.msec.2003.09.009

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JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

IS - 1-2

ER -

Submicron-scale topographical control of cell growth using holographic surface relief grating

Abstract

Bibliographical note

Keywords

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