Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Yunsik Choi; Sanghyuk Lee; Kapyoul Kim; Soo Hyun Kim; Yeun Jun Chung; Charles Lee

doi:10.1038/s12276-018-0115-0

Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Yunsik Choi, Sanghyuk Lee, Kapyoul Kim, Soo Hyun Kim, Yeun Jun Chung, Charles Lee

Department of Life Science

Research output: Contribution to journal › Review article › peer-review

106 Scopus citations

Abstract

Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient’s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.

Original language	English
Article number	99
Journal	Experimental and Molecular Medicine
Volume	50
Issue number	8
DOIs	https://doi.org/10.1038/s12276-018-0115-0
State	Published - 1 Aug 2018

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© 2018, The Author(s).

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abstract = "Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient{\textquoteright}s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.",

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AU - Chung, Yeun Jun

AU - Lee, Charles

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AB - Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient’s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.

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Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Abstract

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