@article{3b56a053554845e997d78ba4df052b33,
title = "Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice",
abstract = "Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient{\textquoteright}s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.",
author = "Yunsik Choi and Sanghyuk Lee and Kapyoul Kim and Kim, {Soo Hyun} and Chung, {Yeun Jun} and Charles Lee",
note = "Funding Information: C.L.: The Korean Healthcare Technology R&D project through the Korean Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (grant no. HI13C2148); the International Research & Development Program of the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (grant no. 2015K1A4A3047851). Y.-J.C.: National Research Foundation of Korea (2017R1E1A1A01074913 and 2012R1A5A2047939). We would also like to thank Ms. Winnie Jane Cha for her help with the figures in this paper. C.L. is a distinguished Ewha Womans University Professor supported in part by the Ewha Womans University Research grant of 2017 and 2018. Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = aug,
day = "1",
doi = "10.1038/s12276-018-0115-0",
language = "English",
volume = "50",
journal = "Experimental and Molecular Medicine",
issn = "1226-3613",
publisher = "Korean Society of Med. Biochemistry and Mol. Biology",
number = "8",
}