Studying cancer immunotherapy using patient-derived xenografts (PDXs) in humanized mice

Yunsik Choi, Sanghyuk Lee, Kapyoul Kim, Soo Hyun Kim, Yeun Jun Chung, Charles Lee

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Cancer immunotherapy is a promising way to eliminate tumor cells by using the patient’s own immune system. Selecting the appropriate animal models to develop or validate preclinical immunotherapeutic trials is now an important aspect of many cancer research programs. Here we discuss the advantages and limitations of using genetically engineered immunodeficient mouse models, patient-derived xenografts (PDXs), and humanized mouse models for developing and testing immunotherapeutic strategies.

Original languageEnglish
Article number99
JournalExperimental and Molecular Medicine
Volume50
Issue number8
DOIs
StatePublished - 1 Aug 2018

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