Study on various fluorescein derivatives as pH sensors

Ha Na Kim, K. M.K. Swamy, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


Various fluorescein derivatives were examined as fluorescent pH sensors. Fluorescein derivatives bearing benzylic amine moieties displayed opposite fluorescent changes compared to those of simple fluorescein derivatives upon pH changes. Photo-induced electron transfer (PET) mechanism controls the fluorescent changes of these derivatives. In this Letter, modulations of pK a values were successfully demonstrated through variations of substituent groups.

Original languageEnglish
Pages (from-to)2340-2343
Number of pages4
JournalTetrahedron Letters
Issue number18
StatePublished - 4 May 2011

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation (NRF) ( 2010-0018895 ), the Converging Research Center Program through the Ministry of Education, Science and Technology ( 2010K001202 ). Mass spectral data were obtained from the Korea Basic Science Institute (Daegu) on a Jeol JMS 700 high resolution mass spectrometer.


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