Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives

Youngjoo Kwon; Younghwa Na

doi:10.1248/cpb.54.248

Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives

Youngjoo Kwon, Younghwa Na

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We have synthesized several new quinophenoxazine analogues and tested their cytotoxicity activities. The results showed that the compounds, 4a and 4b, possessing phenyl ring in the structure have almost same pharmacological capacity with A-62176. This finding suggests that the phenyl ring portion is important to this series of compounds for the activity expression.

Original language	English
Pages (from-to)	248-251
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	54
Issue number	2
DOIs	https://doi.org/10.1248/cpb.54.248
State	Published - Feb 2006

Keywords

Cytotoxicity
Fluoroquinolone
Quinophenoxazine

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AB - We have synthesized several new quinophenoxazine analogues and tested their cytotoxicity activities. The results showed that the compounds, 4a and 4b, possessing phenyl ring in the structure have almost same pharmacological capacity with A-62176. This finding suggests that the phenyl ring portion is important to this series of compounds for the activity expression.

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KW - Quinophenoxazine

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JO - Chemical and Pharmaceutical Bulletin

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Study on the synthesis and cytotoxicity of new quinophenoxazine derivatives

Abstract

Keywords

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