Structural Model of Hospital Nurses’ Compliance with Antineoplastic Drugs Safety Management Guidelines Based on Theory of Planned Behavior

Purpose: This study aims to determine a hypothetical model concerning factors affecting hospital nurses’ compliance with the guidelines of antineoplastic drugs safety management based on the theory of planned behavior. Methods: Data were collected from 339 nurses managing antineoplastic drugs through an online survey conducted from March 23 to April 2, 2022. The data were analyzed using SPSS 28.0 and AMOS 25.0. Results: The hypothetical model had the goodness of fit indices of x2 =370.13 (df=140, p<.001), CFI=.94, SRMR=.07, and RMSEA=.07. Compliance with the guidelines was significantly influenced by compliance intention. Compliance intention and perceived behavioral controls’ explanatory power was 59.9% to explain compliance with the guidelines. In addition, compliance intention was significantly influenced by perceived behavioral control. Perceived behavioral control, attitude toward behavior, and subjective norm had an explanatory power of 65.2% to explain compliance intention. Moreover, perceived behavioral control was influenced by the knowledge of antineoplastic drugs safety management. Conclusion: These findings suggest that for promoting hospital nurses’ compliance with the antineoplastic drugs safety management guidelines, an intervention strategy is required to enhance compliance intention, perceived behavior control, and antineoplastic drugs safety management knowledge.